Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing
The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release. Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels’ crosslinking and physicoch...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2021
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| Online Access: | http://eprints.utm.my/94552/1/SaifulIzwan2021_DevelopmentofAntibacterialDegradableandPh.pdf |
| _version_ | 1796865845127806976 |
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| author | Khan, Muhammad Umar Aslam Iqbal, Iqra Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Raza, Mohsin Ali Sajjad, Amna Jabeen, Faiza Mohamad, Mohd. Riduan Jusoh, Norhana |
| author_facet | Khan, Muhammad Umar Aslam Iqbal, Iqra Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Raza, Mohsin Ali Sajjad, Amna Jabeen, Faiza Mohamad, Mohd. Riduan Jusoh, Norhana |
| author_sort | Khan, Muhammad Umar Aslam |
| collection | ePrints |
| description | The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release. Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels’ crosslinking and physicochemical properties. These hydrogels were characterized using Fourier-transform infrared spec-troscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties. The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media. The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking. In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling. In acidic pH, hydrogels swell the most, while they swell the least at pH 7 or higher. These hydrogels are pH-sensitive and appropriate for controlled drug release. These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions. The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min. To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker–Lonsdale, Hixson, and Peppas). It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509). Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications. |
| first_indexed | 2024-03-05T21:03:17Z |
| format | Article |
| id | utm.eprints-94552 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T21:03:17Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | utm.eprints-945522022-03-31T15:47:11Z http://eprints.utm.my/94552/ Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing Khan, Muhammad Umar Aslam Iqbal, Iqra Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Raza, Mohsin Ali Sajjad, Amna Jabeen, Faiza Mohamad, Mohd. Riduan Jusoh, Norhana Q Science (General) The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release. Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels’ crosslinking and physicochemical properties. These hydrogels were characterized using Fourier-transform infrared spec-troscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties. The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media. The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking. In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling. In acidic pH, hydrogels swell the most, while they swell the least at pH 7 or higher. These hydrogels are pH-sensitive and appropriate for controlled drug release. These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions. The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min. To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker–Lonsdale, Hixson, and Peppas). It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509). Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications. MDPI 2021-10-01 Article PeerReviewed application/pdf en http://eprints.utm.my/94552/1/SaifulIzwan2021_DevelopmentofAntibacterialDegradableandPh.pdf Khan, Muhammad Umar Aslam and Iqbal, Iqra and Mohamed Ansari, Mohamed Nainar and Abd. Razak, Saiful Izwan and Raza, Mohsin Ali and Sajjad, Amna and Jabeen, Faiza and Mohamad, Mohd. Riduan and Jusoh, Norhana (2021) Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing. Molecules, 26 (19). pp. 1-16. ISSN 1420-3049 http://dx.doi.org/10.3390/molecules26195937 DOI:10.3390/molecules26195937 |
| spellingShingle | Q Science (General) Khan, Muhammad Umar Aslam Iqbal, Iqra Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Raza, Mohsin Ali Sajjad, Amna Jabeen, Faiza Mohamad, Mohd. Riduan Jusoh, Norhana Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title | Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_full | Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_fullStr | Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_full_unstemmed | Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_short | Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing |
| title_sort | development of antibacterial degradable and ph responsive chitosan guar gum polyvinyl alcohol blended hydrogels for wound dressing |
| topic | Q Science (General) |
| url | http://eprints.utm.my/94552/1/SaifulIzwan2021_DevelopmentofAntibacterialDegradableandPh.pdf |
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