Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis
Bone tissue engineering is an advanced field for treatment of fractured bones to re-store/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible character-istics. We report synt...
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MDPI AG
2021
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| author | Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Saad Binkadem, Mona Mehboob, Hassan Haider, Adnan Ali Raza, Mohsin Abd. Razak, Saiful Izwan Hasan, Anwarul Amin, Rashid |
| author_facet | Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Saad Binkadem, Mona Mehboob, Hassan Haider, Adnan Ali Raza, Mohsin Abd. Razak, Saiful Izwan Hasan, Anwarul Amin, Rashid |
| author_sort | Aslam Khan, Muhammad Umar |
| collection | ePrints |
| description | Bone tissue engineering is an advanced field for treatment of fractured bones to re-store/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible character-istics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 µm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering. |
| first_indexed | 2024-03-05T21:07:00Z |
| format | Article |
| id | utm.eprints-95788 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T21:07:00Z |
| publishDate | 2021 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | utm.eprints-957882022-05-31T13:19:13Z http://eprints.utm.my/95788/ Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Saad Binkadem, Mona Mehboob, Hassan Haider, Adnan Ali Raza, Mohsin Abd. Razak, Saiful Izwan Hasan, Anwarul Amin, Rashid QM Human anatomy Bone tissue engineering is an advanced field for treatment of fractured bones to re-store/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible character-istics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 µm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering. MDPI AG 2021 Article PeerReviewed Aslam Khan, Muhammad Umar and Al-Arjan, Wafa Shamsan and Saad Binkadem, Mona and Mehboob, Hassan and Haider, Adnan and Ali Raza, Mohsin and Abd. Razak, Saiful Izwan and Hasan, Anwarul and Amin, Rashid (2021) Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis. Nanomaterials, 11 (5). p. 1319. ISSN 2079-4991 http://dx.doi.org/10.3390/nano11051319 |
| spellingShingle | QM Human anatomy Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Saad Binkadem, Mona Mehboob, Hassan Haider, Adnan Ali Raza, Mohsin Abd. Razak, Saiful Izwan Hasan, Anwarul Amin, Rashid Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title | Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title_full | Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title_fullStr | Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title_full_unstemmed | Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title_short | Development of biopolymeric hybrid scaffold-based on AAc/GO/nHAp/TiO2 nanocomposite for bone tissue engineering: In-vitro analysis |
| title_sort | development of biopolymeric hybrid scaffold based on aac go nhap tio2 nanocomposite for bone tissue engineering in vitro analysis |
| topic | QM Human anatomy |
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