Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia
Breast cancer is considered one of the most dangerous types of cancer with a high mortality rate among women worldwide. Potential alternative treatments such as hyperthermia (HT) often associated with poor specific heat distribution within the tumor microenvironment, thus reducing its anticancer pot...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2021
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| Online Access: | http://eprints.utm.my/96239/1/KhairunadwaJemon2021_PreliminaryEvaluationontheEMT6Breast.pdf |
| _version_ | 1796866181679808512 |
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| author | Mohd. Radzi, Muhammad Redza Wan Mohd. Zawawi, Wan Fatin Amira Ahmad Zawawi, Nurliyana Jemon, Khairunadwa |
| author_facet | Mohd. Radzi, Muhammad Redza Wan Mohd. Zawawi, Wan Fatin Amira Ahmad Zawawi, Nurliyana Jemon, Khairunadwa |
| author_sort | Mohd. Radzi, Muhammad Redza |
| collection | ePrints |
| description | Breast cancer is considered one of the most dangerous types of cancer with a high mortality rate among women worldwide. Potential alternative treatments such as hyperthermia (HT) often associated with poor specific heat distribution within the tumor microenvironment, thus reducing its anticancer potential. Owing to the fact that CNTs possessed high thermal conductivity, which could provide a uniform heat distribution, this study aims at exploring the combined effect of CNTs and HT in managing breast tumors. In this study, multiwalled CNTs were functionalized by acid washing protocol and validated by characterization analysis. Female Balb/c mice were inoculated with EMT6 breast cancer cells and then were intratumorally injected once with MWCNTs before being subjected to HT treatment for 3 consecutive days. Tumor progression and survival curves of mice were monitored. Our results demonstrated a successful functionalization of MWCNTs throughout dispersion, FTIR, TGA, XRD and FESEM analysis. Moreover, the combined-treated tumor showed complete eradication and prolonged survival median. The histological data revealed that combined treatment induced significant tumor necrosis post-treatment. Altogether, results from this preliminary study suggested that functionalized CNTs in combination with HT demonstrated a promising effect in eliminating EMT6 breast tumor. |
| first_indexed | 2024-03-05T21:08:20Z |
| format | Conference or Workshop Item |
| id | utm.eprints-96239 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T21:08:20Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | utm.eprints-962392022-07-05T03:56:47Z http://eprints.utm.my/96239/ Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia Mohd. Radzi, Muhammad Redza Wan Mohd. Zawawi, Wan Fatin Amira Ahmad Zawawi, Nurliyana Jemon, Khairunadwa Q Science (General) Breast cancer is considered one of the most dangerous types of cancer with a high mortality rate among women worldwide. Potential alternative treatments such as hyperthermia (HT) often associated with poor specific heat distribution within the tumor microenvironment, thus reducing its anticancer potential. Owing to the fact that CNTs possessed high thermal conductivity, which could provide a uniform heat distribution, this study aims at exploring the combined effect of CNTs and HT in managing breast tumors. In this study, multiwalled CNTs were functionalized by acid washing protocol and validated by characterization analysis. Female Balb/c mice were inoculated with EMT6 breast cancer cells and then were intratumorally injected once with MWCNTs before being subjected to HT treatment for 3 consecutive days. Tumor progression and survival curves of mice were monitored. Our results demonstrated a successful functionalization of MWCNTs throughout dispersion, FTIR, TGA, XRD and FESEM analysis. Moreover, the combined-treated tumor showed complete eradication and prolonged survival median. The histological data revealed that combined treatment induced significant tumor necrosis post-treatment. Altogether, results from this preliminary study suggested that functionalized CNTs in combination with HT demonstrated a promising effect in eliminating EMT6 breast tumor. 2021-05-25 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/96239/1/KhairunadwaJemon2021_PreliminaryEvaluationontheEMT6Breast.pdf Mohd. Radzi, Muhammad Redza and Wan Mohd. Zawawi, Wan Fatin Amira and Ahmad Zawawi, Nurliyana and Jemon, Khairunadwa (2021) Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia. In: 3rd International Conference on Life Sciences and Technology, ICoLiST 2020, 29 September 2020, Malang, Indonesia. http://dx.doi.org/10.1063/5.0052606 |
| spellingShingle | Q Science (General) Mohd. Radzi, Muhammad Redza Wan Mohd. Zawawi, Wan Fatin Amira Ahmad Zawawi, Nurliyana Jemon, Khairunadwa Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title | Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title_full | Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title_fullStr | Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title_full_unstemmed | Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title_short | Preliminary evaluation on the EMT6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| title_sort | preliminary evaluation on the emt6 breast tumor inhibitory activity of carbon nanotubes with hyperthermia |
| topic | Q Science (General) |
| url | http://eprints.utm.my/96239/1/KhairunadwaJemon2021_PreliminaryEvaluationontheEMT6Breast.pdf |
| work_keys_str_mv | AT mohdradzimuhammadredza preliminaryevaluationontheemt6breasttumorinhibitoryactivityofcarbonnanotubeswithhyperthermia AT wanmohdzawawiwanfatinamira preliminaryevaluationontheemt6breasttumorinhibitoryactivityofcarbonnanotubeswithhyperthermia AT ahmadzawawinurliyana preliminaryevaluationontheemt6breasttumorinhibitoryactivityofcarbonnanotubeswithhyperthermia AT jemonkhairunadwa preliminaryevaluationontheemt6breasttumorinhibitoryactivityofcarbonnanotubeswithhyperthermia |