Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor
Monitoring the COVID-19 virus through patients’ saliva is a favorable non-invasive specimen for diagnosis and infection control. In this study, salivary samples of COVID-19 patients collected from 6 patients with the median age of 58.5 years, ranging from 34 to 72 years (2 females and 4 males) were...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier B. V.
2021
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| Online Access: | http://eprints.utm.my/97547/1/AhmadFauziIsmail2021_SustainableAndFastSalivaBasedCOVID19VirusDiagnosisKit.pdf |
| _version_ | 1796866444778012672 |
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| author | Samavati, Alireza Samavati, Zahra Velashjerdi, M. Ismail, Ahmad Fauzi Othman, M. H. D. Eisaabadi B., G. Abdullah, Mohd. Sohaimi Bolurian, Marzieh Bolurian, Mohammadreza |
| author_facet | Samavati, Alireza Samavati, Zahra Velashjerdi, M. Ismail, Ahmad Fauzi Othman, M. H. D. Eisaabadi B., G. Abdullah, Mohd. Sohaimi Bolurian, Marzieh Bolurian, Mohammadreza |
| author_sort | Samavati, Alireza |
| collection | ePrints |
| description | Monitoring the COVID-19 virus through patients’ saliva is a favorable non-invasive specimen for diagnosis and infection control. In this study, salivary samples of COVID-19 patients collected from 6 patients with the median age of 58.5 years, ranging from 34 to 72 years (2 females and 4 males) were analyzed using an Au/fiber Bragg grating (FBG) probe decorated with GO. The probe measures the prevalence of positivity in saliva and the association between the virus density and changes to sensing elements. When the probe is immersed in patients’ saliva, deviation of the detected light wavelength and intensity from healthy saliva indicate the presence of the virus and confirms infection. For a patient in the hyperinflammatory phase of desease, who has virus density of 1.2 × 108 copies/mL in saliva, the maximum wavelength shift and intensity changes after 1600 s were shown to be 1.12 nm and 2.01 dB, respectively. While for a patient in the early infection phase with 1.6 × 103 copies/mL, these values were 0.98 nm and 1.32 dB. The precise and highly sensitive FBG probe proposed in this study was found a reliable tool for quick detection of the COVID-19 virus within 10 s after exposure to patients’ saliva in any stage of the disease. |
| first_indexed | 2024-03-05T21:12:15Z |
| format | Article |
| id | utm.eprints-97547 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T21:12:15Z |
| publishDate | 2021 |
| publisher | Elsevier B. V. |
| record_format | dspace |
| spelling | utm.eprints-975472022-10-18T02:01:52Z http://eprints.utm.my/97547/ Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor Samavati, Alireza Samavati, Zahra Velashjerdi, M. Ismail, Ahmad Fauzi Othman, M. H. D. Eisaabadi B., G. Abdullah, Mohd. Sohaimi Bolurian, Marzieh Bolurian, Mohammadreza TP Chemical technology Monitoring the COVID-19 virus through patients’ saliva is a favorable non-invasive specimen for diagnosis and infection control. In this study, salivary samples of COVID-19 patients collected from 6 patients with the median age of 58.5 years, ranging from 34 to 72 years (2 females and 4 males) were analyzed using an Au/fiber Bragg grating (FBG) probe decorated with GO. The probe measures the prevalence of positivity in saliva and the association between the virus density and changes to sensing elements. When the probe is immersed in patients’ saliva, deviation of the detected light wavelength and intensity from healthy saliva indicate the presence of the virus and confirms infection. For a patient in the hyperinflammatory phase of desease, who has virus density of 1.2 × 108 copies/mL in saliva, the maximum wavelength shift and intensity changes after 1600 s were shown to be 1.12 nm and 2.01 dB, respectively. While for a patient in the early infection phase with 1.6 × 103 copies/mL, these values were 0.98 nm and 1.32 dB. The precise and highly sensitive FBG probe proposed in this study was found a reliable tool for quick detection of the COVID-19 virus within 10 s after exposure to patients’ saliva in any stage of the disease. Elsevier B. V. 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/97547/1/AhmadFauziIsmail2021_SustainableAndFastSalivaBasedCOVID19VirusDiagnosisKit.pdf Samavati, Alireza and Samavati, Zahra and Velashjerdi, M. and Ismail, Ahmad Fauzi and Othman, M. H. D. and Eisaabadi B., G. and Abdullah, Mohd. Sohaimi and Bolurian, Marzieh and Bolurian, Mohammadreza (2021) Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor. Chemical Engineering Journal, 420 (NA). pp. 1-8. ISSN 1385-8947 http://dx.doi.org/10.1016/j.cej.2020.127655 DOI : 10.1016/j.cej.2020.127655 |
| spellingShingle | TP Chemical technology Samavati, Alireza Samavati, Zahra Velashjerdi, M. Ismail, Ahmad Fauzi Othman, M. H. D. Eisaabadi B., G. Abdullah, Mohd. Sohaimi Bolurian, Marzieh Bolurian, Mohammadreza Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title | Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title_full | Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title_fullStr | Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title_full_unstemmed | Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title_short | Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor |
| title_sort | sustainable and fast saliva based covid 19 virus diagnosis kit using a novel go decorated au fbg sensor |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/97547/1/AhmadFauziIsmail2021_SustainableAndFastSalivaBasedCOVID19VirusDiagnosisKit.pdf |
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