Gene selection for high dimensional data using k-means clustering algorithm and statistical approach
Microarray technology can measure thousands of genes which are useful for biologist to study and classify the cancer cells.However, this high dimensional data consists of large number of genes to be examined in regard of small samples size. Thus, selection of relevant genes is a challenging issue in...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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2014
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| Online Access: | https://repo.uum.edu.my/id/eprint/16491/1/IEEE1.pdf |
| _version_ | 1803627195924480000 |
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| author | Ahmad, Farzana Kabir Yusof, Yuhanis Othman, Nor Hayati |
| author_facet | Ahmad, Farzana Kabir Yusof, Yuhanis Othman, Nor Hayati |
| author_sort | Ahmad, Farzana Kabir |
| collection | UUM |
| description | Microarray technology can measure thousands of genes which are useful for biologist to study and classify the cancer cells.However, this high dimensional data consists of large number of genes to be examined in regard of small samples size. Thus, selection of relevant genes is a challenging issue in microarray data analysis and has been a central research focus.This study proposed kmeans clustering algorithm to groups the relevant genes. Several statistical techniques such as Fisher criterion, Golub signal-to-noise, Mann Whitney rank and t-test have been used in deciding the clusters are well separated from one and others. Those genes with high discriminative score will later be used to train the k-NN classifier.The experimental results showed that the proposed gene selection methods able to identify differentially expressed genes with 0.86 ROC score. |
| first_indexed | 2024-07-04T06:02:13Z |
| format | Conference or Workshop Item |
| id | uum-16491 |
| institution | Universiti Utara Malaysia |
| language | English |
| last_indexed | 2024-07-04T06:02:13Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | uum-164912016-04-27T07:19:08Z https://repo.uum.edu.my/id/eprint/16491/ Gene selection for high dimensional data using k-means clustering algorithm and statistical approach Ahmad, Farzana Kabir Yusof, Yuhanis Othman, Nor Hayati QA75 Electronic computers. Computer science Microarray technology can measure thousands of genes which are useful for biologist to study and classify the cancer cells.However, this high dimensional data consists of large number of genes to be examined in regard of small samples size. Thus, selection of relevant genes is a challenging issue in microarray data analysis and has been a central research focus.This study proposed kmeans clustering algorithm to groups the relevant genes. Several statistical techniques such as Fisher criterion, Golub signal-to-noise, Mann Whitney rank and t-test have been used in deciding the clusters are well separated from one and others. Those genes with high discriminative score will later be used to train the k-NN classifier.The experimental results showed that the proposed gene selection methods able to identify differentially expressed genes with 0.86 ROC score. 2014-08-27 Conference or Workshop Item PeerReviewed application/pdf en https://repo.uum.edu.my/id/eprint/16491/1/IEEE1.pdf Ahmad, Farzana Kabir and Yusof, Yuhanis and Othman, Nor Hayati (2014) Gene selection for high dimensional data using k-means clustering algorithm and statistical approach. In: International Conference on Computational Science and Technology (ICCST), 27-28 Aug. 2014, Kota Kinabalu. http://doi.org/10.1109/ICCST.2014.7045188 doi:10.1109/ICCST.2014.7045188 doi:10.1109/ICCST.2014.7045188 |
| spellingShingle | QA75 Electronic computers. Computer science Ahmad, Farzana Kabir Yusof, Yuhanis Othman, Nor Hayati Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title | Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title_full | Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title_fullStr | Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title_full_unstemmed | Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title_short | Gene selection for high dimensional data using k-means clustering algorithm and statistical approach |
| title_sort | gene selection for high dimensional data using k means clustering algorithm and statistical approach |
| topic | QA75 Electronic computers. Computer science |
| url | https://repo.uum.edu.my/id/eprint/16491/1/IEEE1.pdf |
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