Simplifying multivariate survival analysis using global score test methodology
In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments.Treatment comparisons often involve multiple endpoints, and this situation further complicates the analysis of survival data. In the case of tumor patients, endpoints concerning survival tim...
| Egile Nagusiak: | , , |
|---|---|
| Formatua: | Conference or Workshop Item |
| Hizkuntza: | English |
| Argitaratua: |
2015
|
| Gaiak: | |
| Sarrera elektronikoa: | https://repo.uum.edu.my/id/eprint/16798/1/3.pdf |
| _version_ | 1825803768058347520 |
|---|---|
| author | Zain, Zakiyah Aziz, Nazrina Ahmad, Yuhaniz |
| author_facet | Zain, Zakiyah Aziz, Nazrina Ahmad, Yuhaniz |
| author_sort | Zain, Zakiyah |
| collection | UUM |
| description | In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments.Treatment comparisons often involve multiple endpoints, and this situation further complicates the analysis of survival data. In the case of tumor patients, endpoints concerning survival times include: times from tumor removal until the first, the second and the third tumor recurrences, and time to death.For each patient, these endpoints are correlated, and the estimation of the correlation between two score statistics is fundamental in derivation of overall treatment advantage. In this paper, the bi variate survival analysis method using the global score test methodology is extended to multivariate setting. |
| first_indexed | 2024-07-04T06:03:11Z |
| format | Conference or Workshop Item |
| id | uum-16798 |
| institution | Universiti Utara Malaysia |
| language | English |
| last_indexed | 2024-07-04T06:03:11Z |
| publishDate | 2015 |
| record_format | eprints |
| spelling | uum-167982016-04-28T02:07:06Z https://repo.uum.edu.my/id/eprint/16798/ Simplifying multivariate survival analysis using global score test methodology Zain, Zakiyah Aziz, Nazrina Ahmad, Yuhaniz QA75 Electronic computers. Computer science In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments.Treatment comparisons often involve multiple endpoints, and this situation further complicates the analysis of survival data. In the case of tumor patients, endpoints concerning survival times include: times from tumor removal until the first, the second and the third tumor recurrences, and time to death.For each patient, these endpoints are correlated, and the estimation of the correlation between two score statistics is fundamental in derivation of overall treatment advantage. In this paper, the bi variate survival analysis method using the global score test methodology is extended to multivariate setting. 2015-12-11 Conference or Workshop Item PeerReviewed application/pdf en https://repo.uum.edu.my/id/eprint/16798/1/3.pdf Zain, Zakiyah and Aziz, Nazrina and Ahmad, Yuhaniz (2015) Simplifying multivariate survival analysis using global score test methodology. In: 2nd Innovation and Analytics Conference & Exhibition (IACE 2015), 29 September –1 October 2015, TH Hotel, Alor Setar, Kedah, Malaysia. http://doi.org/10.1063/1.4937019 doi:10.1063/1.4937019 doi:10.1063/1.4937019 |
| spellingShingle | QA75 Electronic computers. Computer science Zain, Zakiyah Aziz, Nazrina Ahmad, Yuhaniz Simplifying multivariate survival analysis using global score test methodology |
| title | Simplifying multivariate survival analysis using global score test methodology |
| title_full | Simplifying multivariate survival analysis using global score test methodology |
| title_fullStr | Simplifying multivariate survival analysis using global score test methodology |
| title_full_unstemmed | Simplifying multivariate survival analysis using global score test methodology |
| title_short | Simplifying multivariate survival analysis using global score test methodology |
| title_sort | simplifying multivariate survival analysis using global score test methodology |
| topic | QA75 Electronic computers. Computer science |
| url | https://repo.uum.edu.my/id/eprint/16798/1/3.pdf |
| work_keys_str_mv | AT zainzakiyah simplifyingmultivariatesurvivalanalysisusingglobalscoretestmethodology AT aziznazrina simplifyingmultivariatesurvivalanalysisusingglobalscoretestmethodology AT ahmadyuhaniz simplifyingmultivariatesurvivalanalysisusingglobalscoretestmethodology |