Nonsteroidal anti-inflammatory drugs for pain relief in case of injuries: Is there a risk of bone metabolism disorders and nonunion of bone fractures? by R. A. Karateev, O. A. Nikitinskaya, N. V. Toroptsova, A. E. Karateev

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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…Diclofenac Potassium sachets (DPS) is a new faster-absorption and rapid onset of pain relief drug dosage form of Diclofenac with high analgesic potential.Objective. …”
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Satisfaction with analgesic therapy in patients with rheumatic diseases in real clinical practice, according to the KOMPAS study (Quality of Pain Relief in the Opinion of Patients with Arthritis and Back Pain) by E. Yu. Pogozheva, A. E. Karateev, N. A. Bulgakova, V. N. Amirdzhanova, E. S. Filatova, V. A. Nesterenko, A. M. Lila

“…Patient's satisfaction with treatment is a fundamental indicator of the quality of medical care, which is especially important for assessing the effectiveness of therapy for musculoskeletal pain in rheumatic diseases (RD).Objective: to determine satisfaction of patients with RD with pain relief therapy and to analyze the factors influencing the subjective assessment of analgesic therapy.Patients and methods. …”
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Evaluation of the effectiveness of Tofacitinib in rheumatoid arthritis in real clinical practice: The relationship between pain relief in the first 4 weeks and disease activity after 3–6 months by A. E. Karateev, E. Yu. Pogozheva, V. N. Amirjanova, E. S. Filatova, A. M. Lila, V. I. Mazurov, R. R. Samigullina, A. M. Dadalova, A. Yu. Dyo, D. S. Chakieva, A. A. Baranov, N. A. Lapkina, E. N. Koltsova, N. A. Kiryukhina, I. N. Shchendrigin, T. G. Rasevich, A. F. Davydova, I. V. Semizarova, I. A. Shafieva, I. B. Bashkova, D. A. Bobrikova, D. A. Murtazalieva, I. N. Kushnir, E. V. Kalinina, T. S. Salnikova, I. M. Marusenko, O. V. Semagina, I. B. Vinogradova, D. G. Krechikova, M. Yu. Semchenkova, E. L. Nasonov

“…The number of patients with pain relief ≥50% after 28 days was 59.9%, low RA activity after 3 months. …”
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Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the treatment of osteoarthritis: a follow-up study of pain relief and local symptom reduction) by L. I. Alekseeva, A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzanova, E. S. Filatova, V. A. Nesterenko

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Factors influencing the efficacy of nonsteroidal anti-inflammatory drugs for acute low back pain. The results of the multicenter observational «CARAMBOL» (Clinical Analysis of Resu... by A. E. Karateev, A. M. Lila, E. Yu. Pogozheva, E. S. Filatova, V. N. Amirdzhanova

“…The study estimated the rate of complete pain relief when NSAIDs were used for up to 2 weeks.Results and discussion. …”
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Etoricoxib can be used for chronic nonspecific back pain: a new indication of the well-known drug by A. E. Karateev

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are the main class of analgesics for the relief of acute nonspecific back pain (NSBP) and for the control of chronic one (CNSBP). …”
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Can amtolmetin guacil be useful in surgical practice? by A. E. Karateev

“…Although amtolmetin guaci is mainly used for the relief of pain in diseases of joints and spine (osteoarthritis, back pain, rheumatoid arthritis, etc.), it can be used for pain management in surgical patients.…”
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PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS by A. E. Karateev, D. E. Karateev, O. S. Davydov

“…The relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties. …”
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Lornoxicam in the treatment of acute and chronic musculoskeletal pain by E. Yu. Polishchuk, A. E. Karateev

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used type of drugs in the world and are prescribed for a wide range of indications, including osteoarthritis, rheumatoid arthritis, other diseases of the musculoskeletal system and soft tissues, as well as for the relief of postoperative pain. It is well known that the use of NSAIDs is associated with the risk of gastrointestinal (GIT), cardiovascular (CVS) and kidneys complications. …”
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The therapeutic potential of etoricoxib in clinical practice by A. E. Karateev

“…It has proven to be an effective agent for relief of acute pain (including that in dental practice) and acute gouty arthritis, for long-term treatment of rheumatoid arthritis, ankylosing spondylitis (AS), and osteoarthritis (OA). …”
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Epidural blockades using glucocorticoids: As to how the principles of evidence-based medicine? by A. E. Karateev

“…However, EI of drugs (local anesthetics (LA)) for back pain relief has been practiced ever since 1901 when it was first used by the French physicians J.F. …”
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Dissatisfaction with management of musculoskeletal pain: A global problem and methods of its solution by A. E. Karateev

“…Placebo-controlled trials have demonstrated that monotherapy with the most popular drugs (non-steroidal anti-inflammatory drugs (NSAIDs), opioids, local glucocorticoid injections, duloxetine, etc.) for the treatment of OA and NSBP provides significant pain relief (>50%) in only nearly one-half of patients. …”
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Chronic pain and central sensitization in immuno-inflammatory rheumatic diseases: pathogenesis, clinical manifestations, the possibility of using targeted disease modifying antirhe... by A. E. Karateev, E. L. Nasonov

“…Factors contributing to the development of CS in IIRD are obesity, depression and anxiety, damage of the somatosensory system, insufficient relief of pain in the onset of the disease. Clinical manifestations of CS in IIRD is hyperalgesia, allodinia, «expanded pain» and secondary fibromyalgia. …”
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Russian experience with injectable chondroitin sulfate and glucosamine sulfate: a review of clinical trials by A. E. Karateev, A. M. Lila

“…IGS was  investigated in two trials (n=154), which confirmed its efficacy (total pain relief >50%) and relative safety. Thus, the data of Russian trials suggest that ICS and IGS have good therapeutic potential and favorable tolerance.…”
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The safety of nonsteroidal anti-inflammatory drugs in population-based studies: the benefits of aceclofenac by E. Yu. Pogozheva, A. E. Karateev, V. N. Amirdzhanova

“…Effective pain relief in rheumatology practice is one of the most important criteria for the quality of medical care. …”
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Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017 by A. E. Karateev, A. M. Lila, I. S. Dydykina, P. R. Kamchatnov, S. O. Mazurenko, M. V. Naprienko, D. S. Novikova, O. P. Ostroverkhov, M. V. Pchelintsev

“…The Meeting of Experts of different specialties such as rheumatologists, neurologists, cardiologists and clinical pharmacologists considered the key aspects of the prescription of NSAIDs, the most widely used class of painkillers, including those used for the relief of musculoskeletal pain. It was noted that when choosing NSAIDs, the practitioner should take into account the diagnosis, the planned duration of  analgesic therapy, the intensity of pain, medical history data, the presence of comorbid diseases and risk factors for drug complications. …”
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An old friend: 25 years of meloxicam use in Russia. by A. E. Karateev, E. L. Nasonov, E. Yu. Pogozheva, E. S. Filatova, V. N. Amirdzhanova, V. A. Nesterenko

“…Practically all of these studies have shown good therapeutic results: on average, pain relief is 50–75% of the initial level; good or excellent assessment of the drug effect in 70–80% of patients. …”
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TREATMENT FOR ACUTE/SUBACUTE MUSCULOSKELETAL PAIN, BY USING AN ALGORITHM FOR STEPWISE CHOICE OF ANALGESIC DRUGS AND FOR MONITORING THEIR EFFICACY: PRELIMINARY DATA OF THE ANALGESIC... by N. V. Gontarenko, A. V. Tsurgan, A. E. Karateev

“…The application of the treatment algorithm based on a pathogenetic approach ensures effective and relatively safe relief of MSP in most patients.…”
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Chronic nonspecific (musculoskeletal) low back pain. Guidelines of the Russian Society for the Study of Pain (RSSP) by V. A. Parfenov, N. N. Yakhno, O. S. Davydov, M. L. Kukushkin, M. V. Churyukanov, V. A. Golovacheva, A. I. Isaikin, E. E. Achkasov, G. Yu. Evzikov, A. E. Karateev, F. A. Khabirov, V. A. Shirokov, E. Z. Yakupov

“…It is advisable to identify possible pain sources: pathology of intervertebral disc pathology, facet joints, and sacroiliac joint and myofascial syndrome.An integrated multidisciplinary approach (a high level of evidence), including therapeutic exercises, physical activity optimization, psychological treatments (cognitive behavioral therapy), an educational program (back pain school for patients), and manual therapy, is effective in treating chronic musculoskeletal LBP. For pain relief, one may use nonsteroidal anti-inflammatory drugs in minimally effective doses and in a short cycle, muscle relaxants, and a capsaicin patch, and, if there is depressive disorder, antidepressants (a medium level of evidence). …”
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