Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages by Lester J. Rosario-Rodríguez, Yadira M. Cantres-Rosario, Kelvin Carrasquillo-Carrión, Ana E. Rodríguez-De Jesús, Luz J. Cartagena-Isern, Luis A. García-Requena, Abiel Roche-Lima, Loyda M. Meléndez

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Unsupervised machine learning method for indirect estimation of reference intervals for chronic kidney disease in the Puerto Rican population by Julian Velev, Jack LeBien, Abiel Roche-Lima

“…At the same time, clinical lab data generated in the everyday medical practice contains a wealth of information, that given the correct methodology, can help determine the RIs for each specific segment of the population, including populations that suffer from health disparities. In this work, we develop unsupervised machine learning methods, based on Gaussian mixtures, to determine RIs of analytes related to chronic kidney disease, using millions of routine lab results for the Puerto Rican population. …”
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331 A Machine Learning-based Pharmacogenomic Association Study of Major Adverse Cardiovascular Events (MACEs) in Caribbean Hispanic Patients on Clopidogrel by Luis A. Rosario Arroyo, Luis Rosario-Arroyo, Krystal S Roman-Rodriguez, Carola F Gonzalez-Lebron, Ednalise Santiago, Mariangeli Monera-Paredes, Roberto A. Feliu-Maldonado, Abiel Roche-Lima, Jorge Duconge

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Non-Random Enrichment of Single-Nucleotide Polymorphisms Associated with Clopidogrel Resistance within Risk Loci Linked to the Severity of Underlying Cardiovascular Diseases: The R... by Mariangeli Monero-Paredes, Roberto Feliu-Maldonado, Kelvin Carrasquillo-Carrion, Pablo Gonzalez, Igor B. Rogozin, Abiel Roche-Lima, Jorge Duconge

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Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta by Gabriel Borges-Vélez, Juan A. Arroyo, Yadira M. Cantres-Rosario, Ana Rodriguez de Jesus, Abiel Roche-Lima, Julio Rosado-Philippi, Lester J. Rosario-Rodríguez, María S. Correa-Rivas, Maribel Campos-Rivera, Loyda M. Meléndez

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Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2 by Igor B. Rogozin, Andreu Saura, Eugenia Poliakov, Anastassia Bykova, Abiel Roche-Lima, Youri I. Pavlov, Vyacheslav Yurchenko

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The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection by Anastassia Bykova, Andreu Saura, Galina V. Glazko, Abiel Roche-Lima, Vyacheslav Yurchenko, Igor B. Rogozin

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275 Cultural Adaptation and Implementation of Cognitive Behavior Therapy in a Rural Mental Health Clinic of Puerto Rico by Humberto A. Cruz Esparra, Abiel Roche-Lima, Claudia Amaya-Ardila, Carmen J Buxó-Martínez, Roberto Lewis Fernández, Karen Martínez-González

“…These results will support the feasibility of implementing this approach, addressing mental health disparities, and enhancing treatment engagement and outcomes in underserved populations. …”
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Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes by Igor B. Rogozin, Abiel Roche-Lima, Artem G. Lada, Frida Belinky, Ivan A. Sidorenko, Galina V. Glazko, Vladimir N. Babenko, David N. Cooper, Youri I. Pavlov

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