Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia. by Hoyte, L, Brooks, K, Nagel, S, Akhtar, A, Chen, R, Mardiguian, S, McAteer, M, Anthony, D, Choudhury, R, Buchan, A, Sibson, N

“…In this study, we show specific imaging of vascular cell adhesion molecule (VCAM)-1 expression in a mouse model of middle cerebral artery occlusion (MCAO), and a reduction in this inflammatory response, associated with improved behavioral outcome, as a result of preconditioning. …”

IN-VIVO MAGNETIC RESONANCE IMAGING OF RENAL ISCHAEMIA/REPERFUSION INJURY USING MICROPARTICLES OF IRON OXIDE TARGETING VASCULAR CELL ADHESION MOLECULE 1 by Akhtar, A, Schneider, J, McAteer, M, Chapman, S, Barnes, H, Digby, J, Wood, K, Choudhury, R

An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide. by McAteer, M, Akhtar, A, von Zur Muhlen, C, Choudhury, R

“…We have developed a range of novel ligand-conjugated MPIO for molecular MRI of endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and P-selectin expressed in vascular inflammation, as well as activated platelet thrombosis. …”

In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. by Akhtar, A, Schneider, J, Chapman, S, Jefferson, A, Digby, J, Mankia, K, Chen, Y, McAteer, M, Wood, K, Choudhury, R

“…Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. …”

In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. by Akhtar, A, Schneider, J, Chapman, S, Jefferson, A, Digby, J, Mankia, K, Chen, Y, McAteer, M, Wood, K, Choudhury, R

“… RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. …”

Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. by Melemenidis, S, Jefferson, A, Ruparelia, N, Akhtar, A, Xie, J, Allen, D, Hamilton, A, Larkin, J, Perez-Balderas, F, Smart, S, Muschel, R, Chen, X, Sibson, N, Choudhury, R

“…Angiogenesis is an essential component of tumour growth and, consequently, an important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin is a specific marker of angiogenic vessels and the most prevalent vascular integrin that binds the amino acid sequence arginine-glycine-aspartic acid (RGD). …”