Gastrointestinal permeability and infectious complications in acute pancreatitis; a prospective multicenter study by Besselink, MG, van Santvoort, H, Boermeester, M, Fischer, K, Renooij, W, de Smet, M, Cirkel, G, van Ramshorst, B, Weusten, B, Schaapherder, A, Witteman, B, Ploeg, R, van Goor, H, van Laarhoven, C, Rosman, C, Brink, M, van der Harst, E, Wahab, P, Eijck, v, Dejong, C, Van Erpecum, K, Akkermans, L, Gooszen, H, Pancreatitis, M

Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis. by Besselink, MG, van Santvoort, H, Renooij, W, de Smet, M, Boermeester, M, Fischer, K, Timmerman, H, Ahmed Ali, U, Cirkel, G, Bollen, T, van Ramshorst, B, Schaapherder, A, Witteman, B, Ploeg, R, van Goor, H, van Laarhoven, C, Tan, A, Brink, M, van der Harst, E, Wahab, P, Eijck, v, Dejong, C, van Erpecum, K, Akkermans, L, Gooszen, H

“… OBJECTIVES: To determine the relation between intestinal barrier dysfunction, bacterial translocation, and clinical outcome in patients with predicted severe acute pancreatitis and the influence of probiotics on these processes. …”

Intestinal barrier dysfunction in a randomised placebo-controlled trial of probiotic prophylaxis in acute pancreatitis by Besselink, MG, van Santvoort, H, Boermeester, M, Fischer, K, Renooij, W, de Smet, M, Ali, U, Cirkel, G, Bollen, T, van Ramshorst, B, Weusten, B, Schaapherder, A, Witteman, B, Ploeg, R, van Goor, H, van Laarhoven, C, Tan, A, Brink, M, Van der Harst, E, Wahab, P, Eijck, v, Dejong, C, van Erpecum, K, Akkermans, L, Gooszen, H

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. by Besselink, MG, van Santvoort, H, Buskens, E, Boermeester, M, van Goor, H, Timmerman, H, Nieuwenhuijs, V, Bollen, T, van Ramshorst, B, Witteman, B, Rosman, C, Ploeg, R, Brink, M, Schaapherder, A, Dejong, C, Wahab, P, van Laarhoven, C, van der Harst, E, Eijck, v, Cuesta, M, Akkermans, L, Gooszen, H

“… BACKGROUND: Infectious complications and associated mortality are a major concern in acute pancreatitis. Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce. …”

Probiotic prophylaxis In predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial by Besselink, MG, van Santvoort, H, Buskens, E, Boermeester, M, van Goor, H, Timmerman, H, Nieuwenhuijs, V, Bollen, T, van Ramshorst, B, Witteman, B, Rosman, C, Ploeg, R, Brink, M, Schaapherder, A, Dejong, C, Wahab, P, van Laarhoven, C, van der Harst, E, Eijck, v, Cuesta, M, Akkermans, L, Gooszen, H, Grp, D

[Probiotic prophylaxis in patients with predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial]. by Besselink, MG, van Santvoort, H, Buskens, E, Boermeester, M, van Goor, H, Timmerman, H, Nieuwenhuijs, V, Bollen, T, van Ramshorst, B, Witteman, B, Rosman, C, Ploeg, R, Brink, M, Schaapherder, A, Dejong, C, Wahab, P, van Laarhoven, C, van der Harst, E, Eijck, v, Cuesta, M, Akkermans, L, Gooszen, H

“… OBJECTIVE: To evaluate whether enteral prophylaxis with probiotics in patients with predicted severe acute pancreatitis prevents infectious complications. DESIGN: Multicentre, randomised, double-blind, placebo-controlled trial. …”

Probiotic prophylaxis in patients with predicted severe acute pancreatitis: A randomised, double-blind, placebo-controlled trial by Besselink, M, Van Santvoort, H, Buskens, E, Boermeester, M, Van Goor, H, Timmerman, H, Nieuwenhuijs, V, Bollen, T, Van Ramshorst, B, Witteman, B, Rosman, C, Ploeg, R, Brink, M, Schaapherder, A, Dejong, C, Wahab, P, Van Laarhoven, C, Van Der Harst, E, Van Eijck, G, Cuesta, M, Akkermans, L, Gooszen, H

“…To evaluate whether enteral prophylaxis with probiotics in patients with predicted severe acute pancreatitis prevents infectious complications. Design. …”