Measurement of Cardiac-Specific Biomarkers in the Emergency Department: New Insight in Risk Evaluation by Nadia Aspromonte, Martina Zaninotto, Alberto Aimo, Isabella Fumarulo, Mario Plebani, Aldo Clerico

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Molecular Autopsy of Sudden Cardiac Death in the Genomics Era by Vincenzo Castiglione, Martina Modena, Alberto Aimo, Enrica Chiti, Nicoletta Botto, Simona Vittorini, Benedetta Guidi, Giuseppe Vergaro, Andrea Barison, Andrea Rossi, Claudio Passino, Alberto Giannoni, Marco Di Paolo, Michele Emdin

“…It is particularly useful in cases where traditional autopsy is negative or only shows non-diagnostic features, i.e., in sudden unexplained deaths (SUDs), which are often due to an underlying inherited arrhythmogenic cardiac disease. The final goal of molecular autopsy in SUD cases is to aid medico-legal inquiries and to guide cascade genetic screening of the victim’s relatives. …”
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Pirfenidone for Idiopathic Pulmonary Fibrosis and Beyond by Alberto Aimo, Giosafat Spitaleri, Dari Nieri, Laura Maria Tavanti, Claudia Meschi, Giorgia Panichella, Josep Lupón, Francesco Pistelli, Laura Carrozzi, Antoni Bayes-Genis, Michele Emdin

“…There is some evidence that PFD has antifibrotic actions in various animal models of cardiac disease and a phase II trial on patients with heart failure and preserved ejection fraction has yielded positive results. …”
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Pathophysiological Rationale and Clinical Evidence for Neurohormonal Modulation in Heart Failure with Preserved Ejection Fraction by Vincenzo Castiglione, Francesco Gentile, Nicolò Ghionzoli, Martina Chiriacò, Giorgia Panichella, Alberto Aimo, Giuseppe Vergaro, Alberto Giannoni, Claudio Passino, Michele Emdin

“…Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome resulting from the interaction between cardiac diseases, comorbidities and ageing. HFpEF is characterised by the activation of neurohormonal axes, namely of the renin-angiotensin-aldosterone system and the sympathetic nervous system, although to a lesser extent compared with heart failure with reduced ejection fraction. …”
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