New Three-Finger Protein from Starfish <i>Asteria rubens</i> Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2 by Alexander S. Paramonov, Mikhail A. Shulepko, Alexey M. Makhonin, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Andrey M. Chernikov, Mikhail Yu. Myshkin, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova

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Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of... by Maxim L. Bychkov, Aizek B. Isaev, Alexander A. Andreev-Andrievskiy, Konstantin Petrov, Alexander S. Paramonov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova

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Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors by Alexander S. Paramonov, Milita V. Kocharovskaya, Andrey V. Tsarev, Dmitrii S. Kulbatskii, Eugene V. Loktyushov, Mikhail A. Shulepko, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Zakhar O. Shenkarev

“…Results were compared with the data about human TFPs Lynx1 and SLURP-2 and snake α-neurotoxins WTX and NTII. …”
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Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins by Maxim M. Zaigraev, Ekaterina N. Lyukmanova, Alexander S. Paramonov, Zakhar O. Shenkarev, Anton O. Chugunov

“…Regardless of the linker length between the LU domain and GPI-anchor, the proteins interacted with the membrane by polypeptide parts and N-/O-glycans. Lynx1, Lynx2, Lypd6B, and Ly6H contacted the membrane by the loop regions responsible for interactions with nicotinic acetylcholine receptors, while Lypd6 and CD59 demonstrated unique orientations with accessible receptor-binding sites. …”
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