Iron overload and chelation therapy in hemoglobinopathies by Rayan Bou-Fakhredin, Joseph Elias, Ali T. Taher

“…Iron overload (IOL) is highly prevalent among patients with hemoglobinopathies; both transfusion dependent thalassemia (TDT) and non-transfusion dependent thalassemia (NTDT). …”
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Cardiovascular Complications in β-Thalassemia: Getting to the Heart of It by Nathalie Akiki, Mohammad H. Hodroj, Rayan Bou-Fakhredin, Kamal Matli, Ali T. Taher

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Non-Transfusion-Dependent Thalassemia: An Update on Complications and Management by Joseph Sleiman, Ali Tarhini, Rayan Bou-Fakhredin, Antoine N. Saliba, Maria Domenica Cappellini, Ali T. Taher

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Approaches to management of beta-thalassemia intermedia by Joseph E. Maakaron, Ali T. Taher

“…Thalassemia intermedia is a genetically diverse group of diseases that is the result of an imbalance in the production of the alpha and beta chains with ensuing chronic hemolysis, ineffective erythropoiesis, and iron overload.Resulting complications include bone changes, hypercoagulability, and end-organ damage due to iron overload. …”
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Renal complications in thalassemia by Joseph Sleiman, Ali Tarhini, Ali T. Taher

“…In this review, we evaluate and compare renal involvement in the transfusion-dependent and independent variants of β-Thalassemia, highlighting the pathophysiology of kidney damage that involves iron overload, chronic anemia, and iron chelation therapy. …”
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Non-transfusion dependent thalassemia: translating evidence to guidelines by Afif R. Harb, Antoine N. Saliba, Ali T. Taher

“…The clinical picture of NTDT is governed by the severity of the ineffective erythropoiesis and the chronic hemolytic anemia, which, in turn, lead to iron overload, hypercoagulability, and an array of clinical complications involving almost every organ system. …”
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CYP450 Mediates Reactive Oxygen Species Production in a Mouse Model of β-Thalassemia through an Increase in 20-HETE Activity by Rayan Bou-Fakhredin, Batoul Dia, Hilda E. Ghadieh, Stefano Rivella, Maria Domenica Cappellini, Assaad A. Eid, Ali T. Taher

“…Recent studies suggest that ROS generation in non-transfusion-dependent (NTDT) patients occurs as a result of iron overload. Among the different sources of ROS, the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes and cytochrome P450 (CYP450) have been proposed to be major contributors for oxidative stress in several diseases. …”
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Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity by Angela Vitrano, Khaled M. Musallam, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio, International Working Group on Thalassemia (IWG-THAL)

“…Cluster 3 represented patients with early initiation of transfusion and iron chelation, considerable iron overload, and early mortality from heart failure. …”
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