Genetic Signatures of Positive Selection in Human Populations Adapted to High Altitude in Papua New Guinea by González-Buenfil, R, Vieyra-Sánchez, S, Quinto-Cortés, CD, Oppenheimer, SJ, Pomat, W, Laman, M, Cervantes-Hernández, MC, Barberena-Jonas, C, Auckland, K, Allen, A, Allen, S, Phipps, ME, Huerta-Sanchez, E, Ioannidis, AG, Mentzer, AJ, Moreno-Estrada, A

“…Papua New Guinea (PNG) hosts distinct environments mainly represented by the ecoregions of the Highlands and Lowlands that display increased altitude and a predominance of pathogens, respectively. …”

Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3. by Allen, S, O'Donnell, A, Alexander, N, Mgone, C, Peto, T, Clegg, J, Alpers, M, Weatherall, D

“…We undertook a case-control study of children admitted to hospital in a malarious region of Papua New Guinea. The SAO band 3, detected by the polymerase chain reaction, was present in 0 of 68 children with cerebral malaria compared with six (8.8%) of 68 matched community controls (odds ratio = 0, 95% confidence interval = 0-0.85). …”

Short report: codon 125 polymorphism of CD31 and susceptibility to malaria. by Casals-Pascual, C, Allen, S, Allen, A, Kai, O, Lowe, B, Pain, A, Roberts, D

“…We analyzed data from 442 cases and controls from Papua New Guinea and data from 396 cases and controls from Kenya. …”

A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. by Cockburn, I, Mackinnon, M, O'Donnell, A, Allen, S, Moulds, J, Baisor, M, Bockarie, M, Reeder, J, Rowe, J

“…In this study, we show that RBC CR1 deficiency occurs in up to 80% of healthy individuals from the malaria-endemic regions of Papua New Guinea. This RBC CR1 deficiency is associated with polymorphisms in the CR1 gene and, unexpectedly, with alpha-thalassemia, a common genetic disorder in Melanesian populations. …”

α+-Thalassemia protects children against disease caused by other infections as well as malaria by Allen, S, O'Donnell, A, Alexander, N, Alpers, M, Peto, T, Clegg, J, Weatherall, D

“…Therefore, we undertook a prospective case-control study of children with severe malaria on the north coast of Papua New Guinea, where malaria transmission is intense and α+ - thalassemia affects more than 90% of the population. …”

alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. by Allen, S, O'Donnell, A, Alexander, N, Alpers, M, Peto, T, Clegg, J, Weatherall, D

“…Therefore, we undertook a prospective case-control study of children with severe malaria on the north coast of Papua New Guinea, where malaria transmission is intense and alpha+-thalassemia affects more than 90% of the population. …”