Palladium-catalyzed cascade cyclization of ynamides to azabicycles. by Greenaway, R, Campbell, C, Holton, O, Russell, C, Anderson, E

Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes by Greenaway, R

“…<p>The aim of this work was to investigate palladium-catalysed cyclisations of bromoenynamides in the synthesis of amidodienes, which on further reaction or oxidation can lead to a diverse range of heteroaromatic systems.…”

Palladium-catalyzed asymmetric synthesis of 2-alkynyl oxacycles. by Daniels, D, Thompson, A, Anderson, E

“…Oxyacetylene: Unusual palladium-catalyzed cyclizations of cyclic and acyclic propargylic carbonates give 2-alkynyl oxacycles. …”

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A by Cordonnier, M, Marie-Caroline Cordonnier

Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation by Walker, P, Patrick Ross Walker

“…</p> <p>In the course of investigating the reactivity of these cyclic dienamides, we discovered a new efficient and general route to their synthesis, by employing palladium- or ruthenium-catalysed enynamide cycloisomerisation. …”

Mechanistic insight into palladium-catalyzed cycloisomerization: a combined experimental and theoretical study by Mekareeya, A, Walker, P, Couce-Rios, A, Campbell, C, Steven, A, Paton, R, Anderson, E

“…Extensive (1)H NMR spectroscopic studies and isotope effects support a palladium(II) hydride-mediated pathway and reveal crucial roles of bbeda, water, and the precise nature of the Pd(OAc)2 pre-catalyst. …”

Palladium-catalyzed cyclization of bromoenynamides to tricyclic azacycles: synthesis of trikentrin-like frameworks. by Campbell, C, Greenaway, R, Holton, O, Chapman, H, Anderson, E

“…Palladium-catalyzed cascade cyclization of bromoenynamides equipped with an additional alkyne or ynamide substituent affords azatricyclic products. …”

A palladium-mediated cascade cyclisation approach to the CDE cores of rubriflordilactone A and lancifodilactone G. by Cordonnier, M, Kan, S, Anderson, E

“…Palladium-mediated cascade cyclisation reactions have been applied to the synthesis of the CDE-ring cores of two anti-HIV natural products, rubriflordilactone A and lancifodilactone G.…”

Palladium- and ruthenium-catalyzed cycloisomerization of enynamides and enynhydrazides: a rapid approach to diverse azacyclic frameworks. by Walker, P, Campbell, C, Suleman, A, Carr, G, Anderson, E

Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides by Hou, Y, Ma, J, Yang, H, Anderson, E, Whiting, A, Wu, N

“…The first example of an intramolecular hydroarylation of 1,6-en-α-chloro-enamides was achieved by a palladium-catalysed ligand-free reductive Heck cycloisomerisation with no competing Heck-cyclised by-product.…”

A cascade palladium-mediated cross-coupling/electrocyclization approach to the construction of fused bi- and tricyclic rings. by Kan, S, Anderson, E

“…A versatile palladium-catalyzed cyclization/cross-coupling/electrocyclization strategy for the synthesis of fused bi- and tricyclic ring systems is described. …”

Ligand bite angle-dependent palladium-catalyzed cyclization of propargylic carbonates to 2-alkynyl azacycles or cyclic dienamides. by Daniels, D, Jones, A, Thompson, A, Paton, R, Anderson, E

“…The regioselectivity of the palladium-catalyzed cyclization of propargylic carbonates with sulfonamide nucleophiles is critically dependent on the bite angle of the bidentate phosphine ligand. …”

Development and mechanistic investigations into metal-catalysed cycloisomerisation of enynamides by Mekareeya, A

“…<p>This thesis reports the work on investigations into the mechanism of palladium-catalysed enynamide cycloisomerisations (with Pd(OAc)2 / bis(benzylidene)ethylenediamine (bbeda) catalyst system in particular). …”

Enhancing the synthetic utility of silicon: an investigation into organosilicon chemistry by Bracegirdle, S

“…Unfortunately, despite our considerable efforts, this methodology was found to suffer from reproducibility issues, and thus our attentions subsequently turned to silicon-tethered palladium- and platinum-catalysed processes. These investigations proved to be more fruitful, with the palladium-catalysed methodology affording a small range of silicon-tethered products. …”

Cycloisomerization towards the synthesis of gelsemine and peduncularine by Liang, G

“…This thesis aims to employ palladium-catalyzed ynamide cycloisomerization strategy as a key step towards the synthesis of natural products alkaloids gelsemine and peduncularine. …”

Metal-catalyzed syntheses of abridged CDE rings of rubriflordilactones A and B. by Goh, S, Baars, H, Gockel, B, Anderson, E

“…The development of complementary palladium- and cobalt-catalyzed approaches to tricyclic arylsilanes suitable for elaboration into the CDE ring systems of rubriflordilactones A and B is reported. …”

Combining cycloisomerization with trienamine catalysis: a regiochemically flexible enantio- and diastereoselective synthesis of hexahydroindoles by Chintalapudi, V, Galvin, E, Greenaway, R, Anderson, E

“…The synthesis of polysubstituted hexahydroindoles through trienamine-organocatalyzed cycloadditions of pyrrolidinyl dienals, prepared by palladium-catalyzed cycloisomerization, is reported. …”

Enantioselective synthesis and anti-parasitic properties of aporphine natural products by Pieper, P, McHugh, E, Amaral, M, Tempone, A, Anderson, E

“…In this work, four aporphine natural products were synthesized using an enantioselective, modular and convergent strategy, comprising eight steps in the longest linear sequence; key steps included Bischler-Napieralski cyclization/Noyori asymmetric reduction to construct the tetrahydroisoquinolines, and palladium-catalyzed arylation to close the C ring. …”

Reductive Cyclization of Bromoenynamides with Alcohols as Hydride Source: Synthesis and Reactions of 2-Amidodienes by Greenaway, R, Campbell, C, Chapman, H, Anderson, E

“…Under basic conditions in alcoholic solvents, bromoenynamides undergo palladium-catalyzed cyclization to cyclic 2-amidodienes in good to excellent yields. …”

Total synthesis of rubriflordilactone A by Goh, S

“…</p> <p>Two transition metal-catalysed cascade cyclisation approaches for the formation of the CDE rings of the rubriflordilactones were developed. Palladium-catalysed cyclisation of bromoenediynes and cobalt-catalysed triyne cyclotrimerisation both transform acyclic precursors into 7,6,5-bisannelated arenes in a single step.…”