Showing 1 - 11 results of 11 for search '"Neuro-oncology"', query time: 0.07s Refine Results
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    The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors by Giada Del Baldo, Giada Del Baldo, Francesca Del Bufalo, Claudia Pinacchio, Andrea Carai, Concetta Quintarelli, Biagio De Angelis, Pietro Merli, Antonella Cacchione, Franco Locatelli, Franco Locatelli, Angela Mastronuzzi

    Published 2023-03-01
    “…Major hurdles in the clinical application of this approach in neuro-oncology, however, exist. The peculiar location of brain tumors leads to both a difficulty of access to the tumor mass, shielded by the blood-brain barrier (BBB), and to an increased risk of potentially life-threatening neurotoxicity, due to the primary location of the disease in the CNS and the low intracranial volume reserve. …”
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