ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating by Bulat A. Faizullin, Irina R. Dayanova, Alexey V. Kurenkov, Aidar T. Gubaidullin, Alina F. Saifina, Irek R. Nizameev, Kirill V. Kholin, Mikhail N. Khrizanforov, Aisylu R. Sirazieva, Igor A. Litvinov, Alexandra D. Voloshina, Anna P. Lyubina, Guzel V. Sibgatullina, Dmitry V. Samigullin, Elvira I. Musina, Igor D. Strelnik, Andrey A. Karasik, Asiya R. Mustafina

“…The enhanced level of ROS revealed in HuTu 80 cells incubated with the NPs can be associated with the significant level of their mitochondrial localization.…”
Get full text

Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity by Valeriia V. Sennikova, Alena V. Zalaltdinova, Yulia M. Sadykova, Ayrat R. Khamatgalimov, Almir S. Gazizov, Alexandra D. Voloshina, Anna P. Lyubina, Syumbelya K. Amerhanova, Julia K. Voronina, Elena A. Chugunova, Nurbol O. Appazov, Alexander R. Burilov, Michail A. Pudovik

“…The anti-cancer activity of the obtained compounds was tested in vitro, the most potent compound being 2.6-fold more active against the HuTu 80 cell line than the reference 5-fluorouracil, with a selectivity index > 32.…”
Get full text

Novel Mitochondria-Targeted Amphiphilic Aminophosphonium Salts and Lipids Nanoparticles: Synthesis, Antitumor Activity and Toxicity by Vladimir F. Mironov, Mudaris N. Dimukhametov, Andrey V. Nemtarev, Tatiana N. Pashirova, Olga V. Tsepaeva, Alexandra D. Voloshina, Alexandra B. Vyshtakalyuk, Igor A. Litvinov, Anna P. Lyubina, Anastasiia S. Sapunova, Dinara F. Abramova, Vladimir V. Zobov

“…A high in vitro cytotoxicity of APPs against M-HeLa, HuTu 80, PC3, DU-145, PANC-1, and MCF-7 lines was found. …”
Get full text