The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models by Ginevra Chioccioli Altadonna, Alberto Montalbano, Jessica Iorio, Andrea Becchetti, Annarosa Arcangeli, Claudia Duranti

Subjects: “…hERG1…”
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Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas by Jessica Iorio, Lorenzo Antonuzzo, Emanuela Scarpi, Massimo D’Amico, Claudia Duranti, Luca Messerini, Clotilde Sparano, Damiano Caputo, Daniele Lavacchi, Domenico Borzomati, Alice Antonelli, Lorenzo Nibid, Giuseppe Perrone, Alessandro Coppola, Roberto Coppola, Francesco di Costanzo, Elena Lastraioli, Annarosa Arcangeli

Subjects: “…hERG1 channel…”
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hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract by Elena Lastraioli, Jessica Iorio, Federica Petrelli, Anna Tomezzoli, Serena Battista, Maria Raffaella Ambrosio, Mariella Chiudinelli, Federica De Salvatore, Luca Messerini, Vincenzo Villanacci, Luca Saragoni, Annarosa Arcangeli

Subjects: “…hERG1 potassium channels…”
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Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma by Tiziano Lottini, Claudia Duranti, Jessica Iorio, Michele Martinelli, Rossella Colasurdo, Franco Nicolás D’Alessandro, Matteo Buonamici, Stefano Coppola, Valentina Devescovi, Vincenzo La Vaccara, Alessandro Coppola, Roberto Coppola, Elena Lastraioli, Annarosa Arcangeli

“…With the aim of improving the treatment outcome of PDAC, we tested the effect of combining Gemcitabine with a novel single chain bispecific antibody (scDb) targeting the cancer-specific hERG1/β1 integrin complex. First, using the scDb (scDb-hERG1-β1) in immunohistochemistry (IHC), Western blot (WB) analysis and immunofluorescence (IF), we confirmed the presence of the hERG1/β1 integrin complex in primary PDAC samples and PDAC cell lines. …”
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High throughput clone screening on overexpressed hERG1 and Kv1.3 potassium channels using ion channel reader (ICR) label free technology by Alberto Montalbano, Cesare Sala, Ginevra Chioccioli Altadonna, Andrea Becchetti, Annarosa Arcangeli

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Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex by Lorenzo Santini, Claudia Duranti, Chiara Palandri, Lucrezia Giammarino, Monica Musumeci, Lucia Carlucci, Chiara Capitani, Chiara Capitani, Rossella Colasurdo, Rossella Colasurdo, Fabio Recchia, Elisabetta Cerbai, Raffaele Coppini, Annarosa Arcangeli

“…Cardiac cells were incubated in vitro with i) the scDb-hERG1-β1, ii) the full length anti-hERG1 monoclonal antibody (mAb-hERG1) and iii) its single chain Fragment variable derivative (scFv-hERG1), from which the scDb-hERG1-β1 was assembled. …”
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Ion Channel Targeting with Antibodies and Antibody Fragments for Cancer Diagnosis by Claudia Duranti, Annarosa Arcangeli

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The Activity of Kv 11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells by Sagar Manoli, Stefano Coppola, Claudia Duranti, Matteo Lulli, Lara Magni, Nirmala Kuppalu, Nikolaj Nielsen, Thomas Schmidt, Albrecht Schwab, Andrea Becchetti, Annarosa Arcangeli

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Neonatal Nav1.5 Protein Expression in Human Colorectal Cancer: Immunohistochemical Characterization and Clinical Evaluation by Elena Lastraioli, Scott P. Fraser, R. Mine Guzel, Jessica Iorio, Lapo Bencini, Emanuela Scarpi, Luca Messerini, Vincenzo Villanacci, Giulia Cerino, Niccolo’ Ghezzi, Giuseppe Perrone, Mustafa B. A. Djamgoz, Annarosa Arcangeli

“…Interestingly, nNav1.5 expression co-occurred with other biomarkers associated with metastasis, including hERG1, KCa3.1, VEGF-A, Glut1, and EGFR. Finally, univariate analysis showed that nNav1.5 expression had an impact on progression-free survival. …”
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