The tail of integrin activation. by Anthis, N, Campbell, I

“…Integrins are essential adhesion receptors found on the surfaces of all metazoan cells. …”

Structural studies of integrin activation by Anthis, N, Nicholas J. Anthis

“…<p>Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that link the extracellular matrix to the actin cytoskeleton. …”

Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. by Anthis, N, Haling, JR, Oxley, C, Memo, M, Wegener, K, Lim, C, Ginsberg, M, Campbell, I

“…Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. …”

An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. by Oxley, C, Anthis, N, Lowe, E, Vakonakis, I, Campbell, I, Wegener, K

“…Integrins play a fundamental role in cell migration and adhesion; knowledge of how they are regulated and controlled is vital for understanding these processes. …”

Structural diversity in integrin/talin interactions. by Anthis, N, Wegener, K, Critchley, DR, Campbell, I

“…The adhesion of integrins to the extracellular matrix is regulated by binding of the cytoskeletal protein talin to the cytoplasmic tail of the β-integrin subunit. …”

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. by Anthis, N, Wegener, K, Ye, F, Kim, C, Goult, B, Lowe, E, Vakonakis, I, Bate, N, Critchley, DR, Ginsberg, M, Campbell, I

“…Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by direct binding of talin to the cytoplasmic tail of the beta integrin subunit. …”

The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study. by Kalli, A, Wegener, K, Goult, B, Anthis, N, Campbell, I, Sansom, MS

“…Integrins are cell surface receptors crucial for cell migration and adhesion. …”

The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. by Goult, B, Bouaouina, M, Harburger, D, Bate, N, Patel, B, Anthis, N, Campbell, I, Calderwood, D, Barsukov, I, Roberts, G, Critchley, DR

“…The integrin family of heterodimeric cell adhesion molecules exists in both low- and high-affinity states, and integrin activation requires binding of the talin FERM (four-point-one, ezrin, radixin, moesin) domain to membrane-proximal sequences in the beta-integrin cytoplasmic domain. …”

The structure of an interdomain complex that regulates talin activity. by Goult, B, Bate, N, Anthis, N, Wegener, K, Gingras, A, Patel, B, Barsukov, I, Campbell, I, Roberts, G, Critchley, DR

“…Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. …”