Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia. by Hoyte, L, Brooks, K, Nagel, S, Akhtar, A, Chen, R, Mardiguian, S, McAteer, M, Anthony, D, Choudhury, R, Buchan, A, Sibson, N

“…In this study, we show specific imaging of vascular cell adhesion molecule (VCAM)-1 expression in a mouse model of middle cerebral artery occlusion (MCAO), and a reduction in this inflammatory response, associated with improved behavioral outcome, as a result of preconditioning. …”

In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. by McAteer, M, Sibson, N, von Zur Muhlen, C, Schneider, J, Lowe, A, Warrick, N, Channon, K, Anthony, D, Choudhury, R

“…Endothelial vascular cell adhesion molecule-1 (VCAM-1) and its ligand, alpha4beta1 integrin, are key mediators of leukocyte recruitment, and selective inhibitors that bind to the alpha4 subunit of alpha4beta1 substantially reduce clinical relapse in multiple sclerosis. …”

Magnetic resonance imaging of brain inflammation using microparticles of iron oxide. by McAteer, M, von Zur Muhlen, C, Anthony, D, Sibson, N, Choudhury, R

“…This Chapter describes the methodology of a novel, functional MPIO probe targeting vascular cell adhesion molecule-1 (VCAM-1), for detection of acute brain inflammation in vivo, at a time when pathology is undetectable by conventional MRI. …”

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS. by Evans, M, Serres, S, Khrapitchev, A, Stolp, H, Anthony, D, Talbot, K, Turner, M, Sibson, N

“…To address these issues, we used a multimodal MRI approach targeting structural (T₂, T₁, apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR)), vascular (gadolinium diethylene triamine pentaacetic acid), and endothelial (vascular cell adhesion molecule-microparticles of iron oxide) changes, together with histopathologic analysis from presymptomatic to symptomatic stages of disease. …”

T2-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS by Evans, M, Evans, M, Serres, S, Khrapitchev, A, Stolp, H, Stolp, H, Anthony, D, Talbot, K, Talbot, K, Turner, M, Turner, MR, Sibson, N, Sibson, N

“…To address these issues, we used a multimodal MRI approach targeting structural (T2, T1, apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR)), vascular (gadolinium diethylene triamine pentaacetic acid), and endothelial (vascular cell adhesion molecule-microparticles of iron oxide) changes, together with histopathologic analysis from presymptomatic to symptomatic stages of disease. …”

Molecular MRI enables early and sensitive detection of brain metastases. by Serres, S, Soto, MS, Hamilton, A, McAteer, M, Carbonell, W, Robson, M, Ansorge, O, Khrapitchev, A, Bristow, C, Balathasan, L, Weissensteiner, T, Anthony, D, Choudhury, R, Muschel, R, Sibson, N

“…We have developed a targeted MRI contrast agent based on microparticles of iron oxide that enables imaging of endothelial vascular cell adhesion molecule-1 (VCAM-1). Our objectives here were to determine whether VCAM-1 is up-regulated on vessels associated with brain metastases, and if so, whether VCAM-1-targeted MRI enables early detection of these tumors. …”

Anti-IL-17A treatment reduces clinical score and VCAM-1 expression detected by in vivo magnetic resonance imaging in chronic relapsing EAE ABH mice. by Mardiguian, S, Serres, S, Ladds, E, Campbell, S, Wilainam, P, McFadyen, C, McAteer, M, Choudhury, R, Smith, P, Saunders, F, Watt, G, Sibson, N, Anthony, D

“…We investigated the therapeutic effects of anti-IL-17A in a chronic relapsing EAE ABH mouse model using conventional scoring, quantitative behavioral outcomes, and a novel vascular cell adhesion molecule 1 (VCAM-1)-targeted magnetic resonance imaging (MRI) contrast agent [anti-VCAM-microparticles of iron oxide (MPIO)] to identify conventionally undetectable neuropathology. …”

Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent. by Duffy, B, Choy, M, Riegler, J, Wells, J, Anthony, D, Scott, R, Lythgoe, M

“…In this study we have investigated the potential of a targeted magnetic resonance imaging contrast agent--vascular cell adhesion molecule 1 antibody labelled iron oxide--to image the inflammatory process following status epilepticus in the rat lithium-pilocarpine model. …”