Statins and vein graft failure in coronary bypass surgery by Margaritis, M, Channon, K, Antoniades, C

Statins and vein graft failure in coronary bypass surgery. by Margaritis, M, Channon, K, Antoniades, C

Bypass surgery in a patient with single coronary artery. by Koumallos, N, Paschalis, A, Dimarakis, I, Antoniades, C

Pre-operative inflammation and post-operative atrial fibrillation in coronary artery bypass surgery. by Paschalis, A, Tousoulis, D, Demosthenous, M, Antonopoulos, A, Papaioannou, S, Miliou, A, Koumallos, N, Antoniades, C, Stefanadis, C

NADPH oxidase activity in internal mammary arteries predicts mortality in patients undergoing coronary bypass surgery by Akoumianakis, I, Antonopoulos, AS, Herdman, L, Margaritis, M, Oikonomou, EK, Krasopoulos, G, Petrou, M, Sayeed, R, Channon, KM, Antoniades, C

Pre-operative flow mediated dilatation in patients undergoing coronary artery bypass surgery: Prediction of NO-bioavailability and vascular superoxide production in arterial and vein grafts by Antoniades, C, Mussa, S, Shirodaria, C, Lee, J, Van-Assche, T, Diesch, J, Taggart, D, Channon, K, Leeson, P

Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting. by Antoniades, C, Mussa, S, Shirodaria, C, Lee, J, Diesch, J, Taggart, D, Channon, K, Leeson, P

“…The radial artery is prone to vasospasm after coronary bypass surgery, and endothelial dysfunction is likely to be a key factor. …”

Gene delivery strategies targeting stable atheromatous plaque. by Van-Assche, T, Huygelen, V, Crabtree, M, Antoniades, C

“…Conventional therapeutic options to treat chronic angina pectoris are pharmacological interventions, coronary bypass surgery (CABG) and percutaneous coronary intervention (PCI). …”

Adiponectin As A Link Between Type 2 Diabetes Mellitus And Vascular NADPH-Oxidase Activity In The Human Arterial Wall: The Regulatory Role Of Perivascular Adipose Tissue. by Antonopoulos, A, Margaritis, M, Coutinho, P, Shirodaria, C, Psarros, C, Herdman, L, Sanna, F, De Silva, R, Petrou, M, Sayeed, R, Krasopoulos, G, Lee, R, Digby, J, Reilly, S, Bakogiannis, C, Tousoulis, D, Kessler, B, Casadei, B, Channon, K, Antoniades, C

“…Segments of internal mammary arteries (IMA) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue (Th-AT) were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH-oxidase-derived O2∙(-). …”

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition by Akoumianakis, I, Badi, I, Douglas, G, Chuaiphichai, S, Herdman, L, Akawi, N, Margaritis, M, Antonopoulos, A, Oikonomou, EK, Psarros, C, Galiatsatos, N, Tousoulis, D, Kardos, A, Sayeed, R, Krasopoulos, G, Petrou, M, Schwahn, U, Wohlfart, P, Tennagels, N, Channon, K, Antoniades, C

“…We studied 580 patients with coronary atherosclerosis undergoing coronary artery bypass surgery (CABG), finding that high endogenous insulin was associated with reduced nitric oxide (NO) bioavailability ex vivo in vessels obtained during surgery. …”

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. by Cunnington, C, Van Assche, T, Shirodaria, C, Kylintireas, I, Lindsay, A, Lee, J, Antoniades, C, Margaritis, M, Lee, R, Cerrato, R, Crabtree, M, Francis, J, Sayeed, R, Ratnatunga, C, Pillai, R, Choudhury, R, Neubauer, S, Channon, K

“…METHODS AND RESULTS: Forty-nine patients with coronary artery disease were randomized to receive low-dose (400 mg/d) or high-dose (700 mg/d) BH4 or placebo for 2 to 6 weeks before coronary artery bypass surgery. Vascular function was quantified by magnetic resonance imaging before and after treatment, along with plasma BH4 levels. …”

PHACTR1 modulates vascular compliance but not endothelial function: a translational study by Wood, A, Antonopoulos, A, Chuaiphichai, S, Kyriakou, T, Diaz, R, Al Hussaini, A, Marsh, A-M, Sian, M, Meisuria, M, McCann, G, Rashbrook, VS, Drydale, E, Draycott, S, Polkinghorne, MD, Akoumianakis, I, Antoniades, C, Watkins, H, Channon, KM, Adlam, D, Douglas, G

“…Methods and results Prospectively recruited coronary artery disease (CAD) patients undergoing bypass surgery and retrospectively recruited spontaneous coronary artery dissection (SCAD) patients and matched healthy volunteers were genotyped at the PHACTR1 rs9349379 locus. …”

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease by Cunnington, C, Van Assche, T, Shirodaria, C, Kylintireas, I, Lindsay, A, Lee, J, Antoniades, C, Margaritis, M, Lee, R, Cerrato, R, Crabtree, M, Francis, J, Sayeed, R, Ratnatunga, C, Pillai, R, Choudhury, R, Neubauer, S, Channon, K

“…METHODS AND RESULTS-: Forty-nine patients with coronary artery disease were randomized to receive low-dose (400 mg/d) or high-dose (700 mg/d) BH4 or placebo for 2 to 6 weeks before coronary artery bypass surgery. Vascular function was quantified by magnetic resonance imaging before and after treatment, along with plasma BH4 levels. …”

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”

Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. by Antoniades, C, Van-Assche, T, Shirodaria, C, Diesch, J, Antonopoulos, A, Lee, J, Cunnington, C, Tousoulis, D, Stefanadis, C, Casadei, B, Taggart, D, Channon, K, Leeson, P

“…BACKGROUND: The risk of atrial fibrillation (AF) after coronary bypass surgery has been related to redox state, inflammation, and ischemia. …”

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endotheli... by Antoniades, C, Shirodaria, C, Leeson, P, Antonopoulos, A, Warrick, N, Van-Assche, T, Cunnington, C, Tousoulis, D, Pillai, R, Ratnatunga, C, Stefanadis, C, Channon, K

“…METHODS AND RESULTS: Paired samples of saphenous veins (SVs) and internal mammary arteries (IMAs) were collected from 201 patients undergoing coronary bypass surgery, and serum ADMA was measured pre-operatively. …”

Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease by Akawi, N, Antoniades, C, Checa, A, Channon, K, Neubauer, S, Choudhury, R, Torekov, S, Antonopoulos, A, Akoumianakis, I, Daskalaki, E, Kotanidis, C, Badi, I, Lee, K, Kondo, H, Akbar, N, Polkinghorne, M, Yesilyurt, D, Lundgren, J, Chuaiphichai, S

“…<br><strong>Methods: </strong>We screened for metabolites differentially secreted by thoracic (ThAT) and subcutaneous (ScAT) tissue of obese patients with atherosclerosis (n=48), and linked them with dysregulated vascular redox signalling in 633 patients undergoing coronary bypass surgery. The underlying mechanisms were explored in human aortic endothelial cells (HAEC), and their clinical value was tested against hard clinical endpoints. …”

With the "universal definition," measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after... by Lim, C, van Gaal, W, Testa, L, Cuculi, F, Arnold, JR, Karamitsos, T, Francis, J, Petersen, SE, Digby, J, Westaby, S, Antoniades, C, Kharbanda, R, Burrell, L, Neubauer, S, Banning, A

“…(Myocardial Injury following Coronary Artery bypass Surgery versus Angioplasty: a randomised controlled trial using biochemical markers and cardiovascular magnetic resonance imaging; ISRCTN25699844).…”