Wnt signaling in cardiovascular physiology by Marinou, K, Christodoulides, C, Antoniades, C, Koutsilieris, M

“…Dissecting Wnt pathways involved in atherogenesis and cardiovascular disease may provide crucial insights into novel mechanisms with therapeutic potential for atherosclerosis. © 2012 Elsevier Ltd.…”

Wnt signaling in cardiovascular physiology. by Marinou, K, Christodoulides, C, Antoniades, C, Koutsilieris, M

“…Dissecting Wnt pathways involved in atherogenesis and cardiovascular disease may provide crucial insights into novel mechanisms with therapeutic potential for atherosclerosis.…”

Imaging residual inflammatory cardiovascular risk by Antoniades, C, Antonopoulos, A, Deanfield, J

“…Targeting residual cardiovascular risk in primary and secondary prevention, would allow deployment of novel therapeutic agents, facilitating precision medicine. …”

Assessing inflammatory status in cardiovascular disease. by Tousoulis, D, Antoniades, C, Stefanadis, C

Adiponectin: from obesity to cardiovascular disease. by Antoniades, C, Antonopoulos, A, Tousoulis, D, Stefanadis, C

“…Therefore, any certain conclusion about adiponectin's role in cardiovascular disease seems premature. Despite the rapidly accumulating literature on this adipokine, it is still unclear whether adiponectin is a key mediator or a bystander in cardiovascular disease. …”

Fibrinogen and cardiovascular disease: genetics and biomarkers. by Tousoulis, D, Papageorgiou, N, Androulakis, E, Briasoulis, A, Antoniades, C, Stefanadis, C

“…However, the findings that specific genotypes lead to specific differences in fibrinogen levels, but may not be linked to cardiovascular risk, complicates the hypothesis of causality of fibrinogen in the pathogenesis of cardiovascular disease.…”

Statins and oxidative stress in the cardiovascular system by Margaritis, M, Sanna, F, Antoniades, C

“…Statins are widely established as an important class of medications for primary and secondary prevention of cardiovascular disease. In addition to their lipid-lowering effects, mounting evidence suggests that statins exhibit non-lipid-lowering mediated effects in the cardiovascular system. …”

Statins: pleiotropic regulators of cardiovascular redox state. by Antoniades, C, Channon, K

“…Lipid-lowering treatment with statins is one of the most effective therapeutic strategies in cardiovascular medicine because they reduce cardiovascular risk in both primary and secondary prevention. …”

L-arginine in cardiovascular disease: dream or reality? by Tousoulis, D, Antoniades, C, Tentolouris, C, Goumas, G, Stefanadis, C, Toutouzas, P

“…This amino acid exerts a number of actions in the cardiovascular system, mainly through the production of NO. …”

The role of adipose tissue in cardiovascular health and disease by Oikonomou, E, Antoniades, C

“…The adipose tissue is now recognized as a crucial regulator of cardiovascular health, through the secretion of several bioactive products, including adipocytokines, microvesicles, and gaseous messengers, with a wide range of endocrine and paracrine effects on the cardiovascular system. …”

Adiponectin: From obesity to cardiovascular disease: Etiology and Pathophysiology by Antoniades, C, Antonopoulos, A, Tousoulis, D, Stefanadis, C

“…Therefore, any certain conclusion about adiponectin's role in cardiovascular disease seems premature. Despite the rapidly accumulating literature on this adipokine, it is still unclear whether adiponectin is a key mediator or a bystander in cardiovascular disease. …”

Artificial intelligence in cardiovascular imaging—principles, expectations, and limitations by Antoniades, C, Oikonomou, E

“…The arrival of artificial intelligence (AI) in cardiovascular medicine has introduced many new words and concepts to our dictionary. …”

Exploring the crosstalk between adipose tissue and the cardiovascular system. by Akoumianakis, I, Akawi, N, Antoniades, C

“…Obesity is a clinical entity critically involved in the development and progression of cardiovascular disease (CVD), which is characterised by variable expansion of adipose tissue (AT) mass across the body as well as by phenotypic alterations in AT. …”

Imaging biomarkers for cardiovascular risk prediction with CT techniques by Kluner, LV

“…<p><b>Title:</b> Imaging biomarkers for cardiovascular risk prediction with CT techniques</p> <p><b>Background:</b> Coronary plaque formation, progression and rupture are still the major cause for myocardial infarction. …”

Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system. by Antoniades, C, Antonopoulos, A, Tousoulis, D, Bakogiannis, C, Stefanadi, E, Stefanadis, C

“…In this review article we provide a pharmacokinetic approach for the use of levosimendan in cardiovascular system by discussing its metabolism and mainly the pharmacology of its active metabolites in humans.…”

Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes. by Bakogiannis, C, Tousoulis, D, Androulakis, E, Briasoulis, A, Papageorgiou, N, Vogiatzi, G, Kampoli, A, Charakida, M, Siasos, G, Latsios, G, Antoniades, C, Stefanadis, C

“…The number of circulating EPC has been shown to be inversely correlated with cardiovascular risk factors and vascular function and to predict cardiovascular events independent of both traditional and non-traditional risk factors. …”

Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease. by Briasoulis, A, Tousoulis, D, Papageorgiou, N, Kampoli, A, Androulakis, E, Antoniades, C, Tsiamis, E, Latsios, G, Stefanadis, C

“…The pathological effects of MMPs and TIMPs in cardiovascular diseases involve vascular remodelling, atherosclerotic plaque instability and left ventricular remodelling after myocardial infarction. …”

Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. by Lee, R, Margaritis, M, Channon, K, Antoniades, C

“…Serum lipid hydroperoxides, plasma malondialdehyde or urine F2-isoprostanes are widely used and have a prognostic value in cardiovascular disease. Quantification of oxidative stress at a tissue level is much more accurate. …”

Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease by Woodward, L, Akoumianakis, I, Antoniades, C

“…Adiponectin is one such hormone, exerting endocrine and paracrine effects on the cardiovascular system. At a cellular and molecular level, adiponectin has anti‐inflammatory, antioxidant and anti‐apoptotic roles, thereby mitigating key mechanisms underlying cardiovascular disease (CVD) pathogenesis. …”

Selfies in cardiovascular medicine: welcome to a new era of medical diagnostics by Kotanidis, CP, Antoniades, C