Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1. by Nikolopoulou, A, Tousoulis, D, Antoniades, C, Petroheilou, K, Vasiliadou, C, Papageorgiou, N, Koniari, K, Stefanadi, E, Latsios, G, Siasos, G, Stefanadis, C

“…Serum tumor necrosis factor alpha (TNF-alpha) and soluble vascular cells adhesion molecule (sVCAM-1), were determined by ELISA. …”

The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level. by Tousoulis, D, Antoniades, C, Katsi, V, Bosinakou, E, Kotsopoulou, M, Tsioufis, C, Stefanadis, C

“…Circulating levels of inteleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF-alpha) and soluble vascular cell adhesion molecule (sVCAM-1) were measured by their admission, and at the 1st and 6th week of the study. …”

Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarcta... by Brili, S, Tousoulis, D, Antoniades, C, Vasiliadou, C, Karali, M, Papageorgiou, N, Ioakeimidis, N, Marinou, K, Stefanadi, E, Stefanadis, C

“…Endothelial function was evaluated in the right forearm by gauge-strain plethysmography, and serum levels of interleukin (IL)-1b, IL-6, soluble CD40 ligand (sCD40L), and soluble vascular cell adhesion molecule (sVCAM)-1 were determined by enzyme-linked immunosorbent assay. …”

Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation. by Stefanadi, E, Tousoulis, D, Antoniades, C, Katsi, V, Bosinakou, E, Vavuranakis, E, Triantafyllou, G, Marinou, K, Tsioufis, C, Papageorgiou, N, Latsios, G, Stefanadis, C

“…We investigated the effect of low-dose atorvastatin treatment on the kinetics of cytokine IL-6, vascular cell adhesion molecule (sVCAM-1) and endothelium-derived markers of thrombosis/fibrinolysis such as von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA), post STEMI. …”

Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure. by Tousoulis, D, Antoniades, C, Bosinakou, E, Kotsopoulou, M, Pitsavos, C, Vlachopoulos, C, Panagiotakos, D, Stefanadis, C

“…Serum levels of tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and soluble vascular cell adhesion molecule (sVCAM-1) were determined with ELISA. …”

Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. by Tousoulis, D, Antoniades, C, Tentolouris, C, Tsioufis, C, Toutouza, M, Toutouzas, P, Stefanadis, C

“…Purpose of this study was to investigate the effect of combined administration of antioxidant vitamins C and E on endothelial function and serum levels of inflammatory markers such as tumor necrosis factor alpha (TNF-alpha), interleukines 1b (IL-1b) and 6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in chronic smokers. …”

Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure. by Tousoulis, D, Antoniades, C, Vassiliadou, C, Toutouza, M, Pitsavos, C, Tentolouris, C, Trikas, A, Stefanadis, C

“…AIM: To evaluate the effect of atorvastatin alone or in combination with vitamin E on endothelial function and serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and vascular cells adhesion molecule (sVCAM-1) in patients with ischemic heart failure. …”

Selective serotonin reuptake inhibitors modify the effect of beta-blockers on long-term survival of patients with end-stage heart failure and major depression. by Tousoulis, D, Antoniades, C, Drolias, A, Stefanadi, E, Marinou, K, Vasiliadou, C, Tsioufis, C, Toutouzas, K, Latsios, G, Stefanadis, C

“…At baseline, patients with severe MD had higher serum interleukin 6 (P < .05) and soluble vascular cell adhesion molecule (P < .01). During the follow-up, 167 cardiovascular deaths were reported, and MD was 1 of the major predictors of cardiovascular death (P = .031), whereas treatment with angiotensin receptor inhibitors and statins were also important negative predictors of mortality (P = .036 and P = .039, respectively). …”

Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis. by Antoniades, C, Tousoulis, D, Marinou, K, Papageorgiou, N, Bosinakou, E, Tsioufis, C, Stefanadi, E, Latsios, G, Tentolouris, C, Siasos, G, Stefanadis, C

“…Patients in INS group had higher levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein (MCP-1) and vascular cell adhesion molecule (sVCAM-1), compared to TABL. However, TNF-alpha was negatively correlated with protein C (PrtC) only in INS (r = - 0.726, p = 0.01) but not in TABL group (r = - 0.066, p = 0.738). …”

Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction. by Tousoulis, D, Antoniades, C, Bosinakou, E, Kotsopoulou, M, Tsoufis, C, Marinou, K, Charakida, M, Stefanadi, E, Vavuranakis, M, Latsios, G, Stefanadis, C

“…RESULTS: Patients with UA had significantly higher levels of interleukin-6 (IL-6), soluble vascular cells adhesion molecule (sVCAM-1) and von Willebrand factor (vWF) (p<0.05 vs controls), and lower levels of antithrombin III (ATIII) (p<0.01 vs controls) and protein C (PrtC) (p<0.05 vs controls). …”

Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. by Papageorgiou, N, Tousoulis, D, Psaltopoulou, T, Giolis, A, Antoniades, C, Tsiamis, E, Miliou, A, Toutouzas, K, Siasos, G, Stefanadis, C

“… BACKGROUND/OBJECTIVES: Inter-cellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and tumor necrosis factor-α (TNF-α), are implicated in atherogenesis. …”

Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin... by Tousoulis, D, Antoniades, C, Marinou, K, Vasiliadou, C, Bouras, G, Stefanadi, E, Latsios, G, Siasos, G, Toutouzas, K, Stefanadis, C

“…Forearm vasodilatory response to reactive hyperemia, plasma total homocysteine (tHcy), oxidized LDL (ox-LDL), ET-1 and soluble vascular cell adhesion molecule (sVCAM-1), were evaluated at baseline and 4 hours post methionine loading (4hPML). …”

Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. by Antoniades, C, Tousoulis, D, Tountas, C, Tentolouris, C, Toutouza, M, Vasiliadou, C, Tsioufis, C, Toutouzas, P, Stefanadis, C

“…We examined the effect of vitamin C on endothelial function and levels of soluble vascular cell adhesion molecule (sVCAM-1), interleukin-6 (IL-6) and tumour necrosis factor (TNF-alpha), in DM patients with or without CAD and in non-diabetic subjects. …”

Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia. by Charakida, M, Tousoulis, D, Skoumas, I, Pitsavos, C, Vasiliadou, C, Stefanadi, E, Antoniades, C, Latsios, G, Siasos, G, Stefanadis, C

“…Intercellular cell adhesion molecule (ICAM-1) and interleukin 1 beta (IL-1 beta) serum levels were increased in FH compared to controls (p<0.05 and <0.001, respectively). …”

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of a... by Brili, S, Tousoulis, D, Antonopoulos, A, Antoniades, C, Hatzis, G, Bakogiannis, C, Papageorgiou, N, Stefanadis, C

“…Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA. …”

Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes. by Tousoulis, D, Antoniades, C, Nikolopoulou, A, Koniari, K, Vasiliadou, C, Marinou, K, Koumallos, N, Papageorgiou, N, Stefanadi, E, Siasos, G, Stefanadis, C

“…Circulating levels of sCD40L, interleukin-6 (IL-6), soluble vascular cell adhesion molecule-a (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were determined by enzyme-linked immunosorbent assay (ELISA). …”

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of a... by Brili, S, Tousoulis, D, Antonopoulos, A, Antoniades, C, Hatzis, G, Bakogiannis, C, Papageorgiou, N, Stefanadis, C

“…Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA. …”

Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males. by Tousoulis, D, Koumallos, N, Antoniades, C, Antonopoulos, A, Bakogiannis, C, Milliou, A, Marinou, K, Kallikazarou, E, Stefanadi, E, Mentzikof, D, Stefanadis, C

“…Serum levels of C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in all the participants. …”

Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major. by Aggeli, C, Antoniades, C, Cosma, C, Chrysohoou, C, Tousoulis, D, Ladis, V, Karageorga, M, Pitsavos, C, Stefanadis, C

“…Serum levels of interleukin 6 (IL-6), soluble vascular cell adhesion molecule (sVCAM-1) and soluble intercellular adhesion molecule (sICAM-1) were determined with ELISA. …”