Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort by Fortner, RT, Sarink, D, Schock, H, Johnson, T, Tjønneland, A, Olsen, A, Overvad, K, Affret, A, His, M, Boutron-Ruault, MC, Boeing, H, Trichopoulou, A, Naska, A, Orfanos, P, Palli, D, Sieri, S, Mattiello, A, Tumino, R, Ricceri, F, Bueno-de-Mesquita, HB, Peeters, PH, Van Gils, CH, Weiderpass, E, Lund, E, Quirós, JR, Agudo, A, Sánchez, MJ, Chirlaque, MD, Ardanaz, E, Dorronsoro, M, Key, T, Khaw, KT, Rinaldi, S, Dossus, L, Gunter, M, Merritt, MA, Riboli, E, Kaaks, R

“…Circulating OPG and breast cancer risk has been examined in only one prior study.A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort. by Hosnijeh, F, Lan, Q, Rothman, N, San Liu, C, Cheng, W, Nieters, A, Guldberg, P, Tjønneland, A, Campa, D, Martino, A, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Krogh, V, Tumino, R, Panico, S, Masala, G, Weiderpass, E, Huerta Castaño, J, Ardanaz, E, Sala, N, Dorronsoro, M, Quirós, JR, Sánchez, M

“…However, current evidence is limited and based on a relatively small number of cases. Using a nested case-control study, we extended these findings with a focus on subtype-specific analyses. …”

The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition by Smith Byrne, K, Appleby, PN, Key, TJ, Holmes, MV, Fensom, GK, Agudo, A, Ardanaz, E, Boeing, H, Bueno-de-Mesquita, HB, Chirlaque, MD, Kaaks, R, Larrañaga, N, Palli, D, Perez-Cornago, A, Quirós, JR, Ricceri, F, Sánchez, MJ, Tagliabue, G, Tsilidis, KK, Tumino, R, Fortner, RT, Ferrari, P, PRACTICAL Consortium, Riboli, E, Lilja, H, Travis, RC

“…Patients and methods A nested case–control study was conducted with the European Prospective Investigation into Cancer and Nutrition (EPIC) with 1871 cases and 1871 matched controls. …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, M, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…Objective: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. Design: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, MD, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…OBJECTIVE: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. DESIGN: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Key, T, Allen, N, Appleby, P, Roddam, A, Rinaldi, S, Egevad, L, Gann, P, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Sieri, S, Vineis, P, Palli, D, Quirós, JR, Ardanaz, E

“…We examined the hypothesis that serum concentrations of circulating androgens and sex hormone binding globulin (SHBG) are associated with risk for prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort by Fortner, RT, Vitonis, AF, Schock, H, Hüsing, A, Johnson, T, Fichorova, RN, Fashemi, T, Yamamoto, HS, Tjønneland, A, Hansen, L, Overvad, K, Boutron-Ruault, M-C, Kvaskoff, M, Severi, G, Boeing, H, Trichopoulou, A, Benetou, V, La Vecchia, C, Palli, D, Sieri, S, Tumino, R, Matullo, G, Mattiello, A, Onland-Moret, NC, Peeters, PH, Weiderpass, E, Gram, IT, Jareid, M, Quirós, JR, Duell, EJ, Sánchez, M-J, Chirlaque, MD, Ardanaz, E, Larrañaga, N, Nodin, B, Brändstedt, J, Idahl, A, Khaw, K-T, Allen, N, Gunter, M, Johansson, M, Dossus, L, Merritt, MA, Riboli, E, Cramer, DW, Kaaks, R, Terry, KL

“…<br/><strong>Methods: </strong>We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. by Ose, J, Fortner, RT, Schock, H, Peeters, P, Onland-Moret, N, Bueno-de-Mesquita, H, Weiderpass, E, Gram, I, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E

“…METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). …”

Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC. by Travis, R, Allen, N, Appleby, P, Price, A, Kaaks, R, Chang-Claude, J, Boeing, H, Aleksandrova, K, Tjønneland, A, Johnsen, N, Overvad, K, Ramón Quirós, J, González, C, Molina-Montes, E, Sánchez, M, Larrañaga, N, Castaño, J, Ardanaz, E, Khaw, K, Wareham, N, Trichopoulou, A, Karapetyan, T, Rafnsson, S, Palli, D, Krogh, V

“…We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer. by Campa, D, Hüsing, A, Dostal, L, Stein, A, Drogan, D, Boeing, H, Tjønneland, A, Roswall, N, Østergaard, J, Overvad, K, Rodríguez, L, Bonet, C, Sánchez, M, Larrañaga, N, Huerta, J, Ardanaz, E, Khaw, K, Wareham, N, Travis, R, Allen, N, Trichopoulou, A, Zylis, D, Karapetyan, T, Palli, D, Sieri, S

“…Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Spencer, E, Allen, N, Appleby, P, Roddam, A, Overvad, K, Johnsen, N, Olsen, A, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Bueno-de-Mesquita, H, Ros, M, Sacerdote, C, Palli, D, Tumino, R, Berrino, F, Trichopoulou, A, Dilis, V, Trichopoulos, D, Chirlaque, MD, Ardanaz, E, Larranaga, N, Gonzalez, C

“…We examined plasma concentrations of phyto-oestrogens in relation to risk for subsequent prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC Cohort by Carayol, M, Leitzmann, MF, Ferrari, P, Zamora-Ros, R, Achaintre, D, Stepien, M, Schmidt, JA, Travis, RC, Overvad, K, Tjønneland, A, Hansen, L, Kaaks, R, Kühn, T, Boeing, H, Bachlechner, U, Trichopoulou, A, Bamia, C, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Quirós, JR, Sánchez-Cantalejo, E, Huerta, JM, Ardanaz, E, Arriola, L, Agudo, A, Nilsson, J, Melander, O, Bueno-de-Mesquita, B, Peeters, PH, Wareham, N, Khaw, KT, Jenab, M, Key, TJ, Scalbert, A, Rinaldi, S

“…Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). …”

Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study. by Hosnijeh, F, Matullo, G, Russo, A, Guarrera, S, Modica, F, Nieters, A, Overvad, K, Guldberg, P, Tjønneland, A, Canzian, F, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Tagliabue, G, Tumino, R, Panico, S, Palli, D, Olsen, K, Weiderpass, E, Dorronsoro, M, Ardanaz, E, Chirlaque, MD, Sánchez, M

“…The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. …”

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk by Campa, D, Hüsing, A, McKay, J, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, N, Gils, V, Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, R, Key, T, Wareham, N, Khaw, K, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R, Canzian, F

“…<br/><br/> <b>Methods:</b> we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.…”

Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort by Fortner, R, Hüsing, A, Kühn, T, Konar, M, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Severi, G, Fournier, A, Boeing, H, Trichopoulou, A, Benetou, V, Orfanos, P, Masala, G, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H, Peeters, P, Weiderpass, E, Gram, I, Gavrilyuk, O, Quirós, J, Huerta, J, Ardanaz, E, Larrañaga, N, Lujan-Barroso, L, Sánchez-Cantalejo, E, Butt, S, Borgquist, S, Idahl, A, Lundin, E, Khaw, K, Allen, N, Rinaldi, S, Dossus, L, Gunter, M, Merritt, M, Tzoulaki, I, Riboli, E, Kaaks, R

“…Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. …”

Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. by Rohrmann, S, Linseisen, J, Becker, S, Allen, N, Schlehofer, B, Overvad, K, Olsen, A, Tjønneland, A, Melin, B, Lund, E, Vineis, P, Grioni, S, Tumino, R, Palli, D, Mattiello, A, Bonet, C, Chirlaque, MD, Sánchez, M, Rodríguez, L, Dorronsoro, M, Ardanaz, E, Lagiou, P, Trichopoulou, A, Trichopoulos, D, Dossus, L

“…METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. …”

Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). by Rinaldi, S, Dossus, L, Lukanova, A, Peeters, P, Allen, N, Key, T, Bingham, S, Khaw, K, Trichopoulos, D, Trichopoulou, A, Oikonomou, E, Pera, G, Larrañaga, N, Martinez-Garcia, C, Ardanaz, E, Quirós, JR, Tormo, M, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Linseisen, J, Schulz, M, Boeing, H, Gils, v

“…We investigated the association between prediagnostic serum levels of androgens and sex hormone-binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. …”

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort by Duell, E, Lujan-Barroso, L, Llivina, C, Muñoz, X, Jenab, M, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Boeing, H, Buijsse, B, Canzian, F, Johnson, T, Dalgård, C, Overvad, K, Tjønneland, A, Olsen, A, Sánchez, S, Sánchez-Cantalejo, E, Huerta, J, Ardanaz, E, Dorronsoro, M, Khaw, K, Travis, R, Trichopoulou, A, Trichopoulos, D

“…We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. …”