ATP-SENSITIVE K-CHANNELS IN GUINEA-PIG ISOLATED SUBSTANTIA-NIGRA NEURONS ARE MODULATED BY CELLULAR-METABOLISM by Roper, J, Hainsworth, A, Ashcroft, F

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding by Puljung, M, Vedovato, N, Usher, S, Ashcroft, F

“…The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). …”

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. by Loussouarn, G, Pike, L, Ashcroft, F, Makhina, E, Nichols, C

“…ATP and MgADP regulate K(ATP) channel activity and hence potentially couple cellular metabolism to membrane electrical activity in various cell types. …”

Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. by Lawrence, C, Proks, P, Rodrigo, G, Jones, P, Hayabuchi, Y, Standen, N, Ashcroft, F

“…KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide blocks recombinant beta-cell KATP channels (Kir6.2/SUR1) but not heart (Kir6.2/SUR2A) or smooth muscle (Kir6.2/SUR2B) KATP channels with high potency. …”

Direct interaction of Na-azide with the KATP channel. by Trapp, S, Ashcroft, F

“…We conclude that, in addition to its well-established inhibitory effect on cellular metabolism, which leads to activation of KATP channels in intact cells, intracellular Na-azide has direct effects on the KATP channel. …”