Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota by Mahmoud A. Ghannoum, Lisa Long, Christopher G. Bunick, James Q. Del Rosso, Ahmed Gamal, Stephen K. Tyring, Thomas S. McCormick, Ayman Grada

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Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity by Ayman Grada, James Q. Del Rosso, James Q. Del Rosso, Angela Y. Moore, Angela Y. Moore, Linda Stein Gold, Julie Harper, Giovanni Damiani, Giovanni Damiani, Giovanni Damiani, Katharina Shaw, Sabine Obagi, Raidah J. Salem, S. Ken Tanaka, Christopher G. Bunick, Christopher G. Bunick

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Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy by Rachel E. Tao, Stuti Prajapati, Jessica N. Pixley, Ayman Grada, Steven R. Feldman

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Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota by Ines B. Moura, Ayman Grada, William Spittal, Emma Clark, Duncan Ewin, James Altringham, Emilio Fumero, Mark H. Wilcox, Mark H. Wilcox, Anthony M. Buckley, Anthony M. Buckley

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Prescribing Trends for Acne Vulgaris Visits in the United States by Patrick O. Perche, Gabrielle M. Peck, Lillian Robinson, Ayman Grada, Alan B. Fleischer, Steven R. Feldman

“…Oral minocycline was also the most common antibiotic prescribed by family physicians, followed by oral doxycycline and oral clindamycin, respectively. …”
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Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation by Christopher G. Bunick, Jonette Keri, S. Ken Tanaka, Nika Furey, Giovanni Damiani, Jodi L. Johnson, Ayman Grada

“…The anti-inflammatory activity of sarecycline was comparable to doxycycline and minocycline in a rat paw edema model. Here, we review the antibacterial mechanisms of sarecycline and report results of in vivo studies of infection and inflammation.…”
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Sarecycline Demonstrates Clinical Effectiveness against Staphylococcal Infections and Inflammatory Dermatoses: Evidence for Improving Antibiotic Stewardship in Dermatology by Ayman Grada, Mahmoud A. Ghannoum, Christopher G. Bunick

“…Concerns about antibiotic resistance and protecting the human/host microbiome beg the question whether broad-spectrum tetracyclines such as doxycycline and minocycline should be prescribed at such a high rate by dermatologists when a narrow-spectrum tetracycline derivative, sarecycline, exists. …”
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