Deep brain stimulation for pain relief: a meta-analysis. by Bittar, R, Kar-Purkayastha, I, Owen, S, Bear, R, Green, A, Wang, S, Aziz, T

“…To better understand its efficacy, we performed a meta-analysis of DBS for pain relief. MEDLINE (1966 to February 2003) and EMBASE (1980 to January 2003) databases were searched using key words deep brain stimulation, sensory thalamus, periventricular gray and pain. …”

Characteristics of local field potentials correlate with pain relief by deep brain stimulation by Huang, Y, Luo, H, Green, A, Aziz, T, Wang, S

“…The LFPs were quantified using spectral and time-frequency analysis, the relationship between the LFPs and pain relief was quantified with nonlinear correlation analysis.The theta oscillations of both sensory thalamus and PVAG correlated inversely with pain relief. …”

Oscillatory neural representations in the sensory thalamus predict neuropathic pain relief by deep brain stimulation by Huang, Y, Green, A, Hyam, J, Fitzgerald, J, Aziz, T, Wang, S

“…However, there is a lack of investigation of the relationship between sensory thalamic oscillations and pain relief in patients with neuropathic pain. This study aims to identify the oscillatory neural characteristics correlated with pain relief induced by deep brain stimulation (DBS), and develop a quantitative model to predict pain relief by integrating characteristic measures of the neural oscillations.…”

MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain. by Mohseni, H, Smith, P, Parsons, C, Young, K, Hyam, J, Stein, J, Stein, A, Green, A, Aziz, T, Kringelbach, M

“…Using this beamforming method, we examined changes in whole-brain activity comparing pain relief achieved with deep brain stimulation (DBS ON) and compared with pain experienced with no stimulation (DBS OFF). …”

Dynamic neural state identification in deep brain local field potentials of neuropathic pain by Luo, H, Huang, Y, Du, X, Zhang, Y, Green, A, Aziz, T, Wang, S

“…The occurrence of neural states based on theta and alpha oscillations were correlated to the degree of pain relief by deep brain stimulation. In the PVAG LFPs, the occurrence of the state with high activity levels of theta oscillations independent of alpha and the state with low-level alpha and high-level theta oscillations were significantly correlated with pain relief by deep brain stimulation. …”

Thalamic field potentials in chronic central pain treated by periventricular gray stimulation -- a series of eight cases. by Nandi, D, Aziz, T, Carter, H, Stein, J

“…In addition, local field potentials (FPs) were recorded from the sensory thalamus during PVG stimulation. Maximum pain relief was obtained with 5-35 Hz stimulation while 50-100 Hz made the pain worse. …”

EFNS guidelines on neurostimulation therapy for neuropathic pain. by Cruccu, G, Aziz, T, Garcia-Larrea, L, Hansson, P, Jensen, T, Lefaucheur, J, Simpson, B, Taylor, R

“…Pharmacological relief of neuropathic pain is often insufficient. …”

Deep brain stimulation for phantom limb pain. by Bittar, R, Otero, S, Carter, H, Aziz, T

“…This study assessed the clinical outcome of deep brain stimulation of the periventricular grey matter and somatosensory thalamus for the relief of chronic neuropathic pain associated with phantom limb in three patients. …”

Phantom limb pain relieved with different modalities of central nervous system stimulation: a clinical and functional imaging case report of two patients. by Nandi, D, Yianni, J, Humphreys, J, Wang, S, O'sullivan, V, Shepstone, B, Stein, J, Aziz, T

“…We describe two cases of PLP that have been satisfactorily treated with CNS stimulation (motor cortex and then periventricular gray in one and spinal cord in the other) and have been subjected to single photon emission computed tomography (SPECT) studies when in pain and then during stimulation with recorded pain relief. We found that regardless of the site of stimulation in the CNS, pain relief is associated with blood flow changes in similar areas of the brain, mainly the parietal and cingulate cortex and also in the thalamic nuclei and the central gray matter. …”

Thalamic field potentials during deep brain stimulation of periventricular gray in chronic pain. by Nandi, D, Liu, X, Joint, C, Stein, J, Aziz, T

“…In addition, local field potentials (FPs) were recorded from the sensory thalamus during PVG stimulation. Maximum pain relief was obtained with 5-25 Hz stimulation while 50-100 Hz made the pain worse. …”

Deep brain stimulation: a new treatment for hypertension? by Green, A, Wang, S, Bittar, R, Owen, S, Paterson, D, Stein, J, Bain, P, Shlugman, D, Aziz, T

“…We report a 61-year-old hypertensive man who underwent deep brain stimulation of the periventricular/periaqueductal grey area for the relief of chronic neuropathic pain affecting his oral cavity and soft palate. …”

Neuromodulation in pain by Parker, TOA

“…There were significant neurophysiologic markers of pain (cortical theta activity) and pain relief (cortical beta activity) among dorsal root ganglion stimulation patients, with efficacy in modulating sensory, cognitive and autonomic indicators in chronic pain patients. …”

Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain. by Owen, S, Heath, J, Kringelbach, M, Green, A, Pereira, E, Jenkinson, E, Jegan, T, Stein, J, Aziz, T

“…A pre-operative DTI was obtained for each patient, who was then implanted with deep brain stimulation electrodes in the periventricular/periaqueductal grey area with good pain relief. Using seeds from the postoperative MRI scan, probabilistic tractography was performed from the pre-operative DTI.…”

Deep brain stimulation for chronic pain investigated with magnetoencephalography. by Kringelbach, M, Jenkinson, N, Green, A, Owen, S, Hansen, P, Cornelissen, P, Holliday, I, Stein, J, Aziz, T

“…Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.…”

Preoperative DTI and probabilistic tractography in an amputee with deep brain stimulation for lower limb stump pain. by Owen, S, Heath, J, Kringelbach, M, Stein, J, Aziz, T

“…A preoperative DTI was obtained from the patient, who then received DBS surgery in the PAG/PVG area with good pain relief. The postoperative MRI scan showing electrode placement was used to calculate four seed areas to represent the contacts on the Medtronic 3387 electrode. …”

Deep brain stimulation for chronic pain by Kringelbach, M, Pereira, E, Green, A, Owen, S, Aziz, T

“…In particular, we show how DBS can be used in conjunction with methods such as local field potentials and magnetoencephalography to map the underlying mechanisms of normal and abnormal oscillatory synchronization in the brain related to the pleasure of pain relief. © 2010 by Nova Science Publishers, Inc. All rights reserved.…”

Deep brain stimulation for chronic pain by Kringelbach, M, Pereira, E, Green, A, Owen, S, Aziz, T

“…In particular, we show how DBS can be used in conjunction with methods such as local field potentials and magnetoencephalography to map the underlying mechanisms of normal and abnormal oscillatory synchronization in the brain related to the pleasure of pain relief. © 2009 Nova Science Publishers, Inc.…”

Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. by Mohseni, H, Kringelbach, M, Probert Smith, P, Green, A, Parsons, C, Young, K, Brittain, J, Hyam, J, Schweder, P, Stein, J, Aziz, T

“…We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief.…”

Application of a Null-Beamformer to Source Localisation in MEG Data of Deep Brain Stimulation by Mohseni, H, Kringelbach, M, Smith, P, Green, A, Parsons, C, Young, K, Brittain, J, Hyam, J, Schweder, P, Stein, J, Aziz, T, IEEE

“…We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief. © 2010 IEEE.…”

Anterior cingulotomy improves malignant mesothelioma pain and dyspnoea. by Pereira, E, Paranathala, M, Hyam, J, Green, A, Aziz, T

“…Quality of life improvements were also seen for 2 months after surgery and pain relief was sustained from surgery to death. Arterial blood gas and lung function tests were unchanged by surgery, suggesting a reduction in pain and dyspnoea awareness by cingulotomy. …”