Elimination therapy for the endemic malarias. by Baird, J

“…Most malaria diagnosed outside endemic zones occurs in patients experiencing the consequences of what was likely a single infectious bite by an anopheline mosquito. …”

Elimination therapy for the endemic malarias by Baird, J

“…Most malaria diagnosed outside endemic zones occurs in patients experiencing the consequences of what was likely a single infectious bite by an anopheline mosquito. …”

Reinventing primaquine for endemic malaria. by Baird, J

Plasmodium falciparum malaria endemicity in Indonesia in 2010. by Elyazar, I, Gething, P, Patil, A, Rogayah, H, Kusriastuti, R, Wismarini, D, Tarmizi, SN, Baird, J, Hay, S

“…After quality control, 2,516 were included into a national database of age-standardized 2-10 year old PfPR data (PfPR(2-10)) for endemicity mapping. A Bayesian MBG procedure was used to create a predicted surface of PfPR(2-10) endemicity with uncertainty estimates. …”

A focus of endemic malaria in central Java. by Baird, J, Sismadi, P, Masbar, S, Ramzan, A, Purnomo, B, Sekartuti, Tjitra, E, Rumoko, B, Arbani, P

“…This report describes one of the few remaining foci of endemic malaria on the island of Java, the Kokap subdistrict, near the Southcentral coast. …”

Plasmodium vivax malaria endemicity in Indonesia in 2010 by Elyazar, I, Gething, P, Patil, A, Rogayah, H, Sariwati, E, Palupi, N, Tarmizi, SN, Kusriastuti, R, Baird, J, Hay, S

“…BACKGROUND: Plasmodium vivax imposes substantial morbidity and mortality burdens in endemic zones. Detailed understanding of the contemporary spatial distribution of this parasite is needed to combat it. …”

Chemotherapeutics challenges in developing effective treatments for the endemic malarias by Baird, J

“…The endemic malarias threaten the several billion people residing where transmission occurs. …”

Chemotherapeutics challenges in developing effective treatments for the endemic malarias by Baird, J

“…The endemic malarias threaten the several billion people residing where transmission occurs. …”

Primaquine toxicity forestalls effective therapeutic management of the endemic malarias. by Baird, J

“…These failures forestalled the emergence of therapies practical for use in endemic zones, especially in the context of eliminating transmission.…”

Primaquine toxicity forestalls effective therapeutic management of the endemic malarias by Baird, J

“…Therapies effective against all species and stages would likely prove more practical in endemic zones, especially if safely administered without laboratory screening for contraindications. …”

Growing evidence of Plasmodium vivax across malaria-endemic Africa by Twohig, K, Pfeffer, D, Baird, J, Price, R, Zimmerman, P, Hay, S, Gething, P, Battle, K, Howes, R

“…Since 2010, the number of studies identifying P. vivax endemic to Africa has expanded considerably, with 88 new scientific reports published since a review of evidence in 2015, approximately doubling the available data. …”

A long neglected world malaria map: Plasmodium vivax endemicity in 2010. by Gething, P, Elyazar, I, Moyes, C, Smith, D, Battle, K, Guerra, C, Patil, A, Tatem, A, Howes, R, Myers, M, George, D, Horby, P, Wertheim, H, Price, R, Müeller, I, Baird, J, Hay, S

“…Here we present the first systematic effort to map the global endemicity of this hitherto neglected parasite</p> <h4>Methodology and Findings</h4><pwe (par)="" (pvpr)="" (pvpr1–99)="" 1985="" 1–99="" 2.5="" 2010="" 22%="" 3.5%="" 565="" 6%="" 7%pvpr1–99.="" 82%="" 9%="" 9,970="" a="" africa,="" africa.="" age="" age-standardised="" americas="" an="" and="" approach="" area="" areas="" asia="" assembly="" at="" bayesian="" billion="" but="" central="" coinciding="" collected="" constrained="" contained="" contributed="" contributing="" data="" dense="" duffy="" earlier="" east="" endemic="" endemicity="" estimate="" every="" exceeding="" first="" frequency="" from="" generally="" geographical="" geopositionedp.="" geostatistical="" global="" globally.="" grid="" guinea="" high="" highest="" home="" horn,="" important="" in="" incorporated="" india="" indonesia="" km="" limits="" madagascar="" meant="" model="" model-based="" myanmar.="" narrow="" negative="" negativity="" new="" of="" ofp.="" on="" only="" our="" p="" p.="" papua="" par="" par.="" par.<="" particularly="" parts="" people="" phenotype="" point="" populated="" populations="" predicted="" predictions,="" range="" rarely="" rate="" region="" relatively="" resolution="" risk="" south="" sparsely="" spatiotemporal="" square.="" stable="" suppress="" surveys="" the="" throughout="" to="" transmission="" transmission,="" transmission.="" updated="" used="" vivax="" vivaxparasite="" vivaxtransmission,="" was="" were="" with="" within="" world,="" year=""> <h4>Conclusions and Significance</h4> <p>This detailed depiction of spatially varying endemicity is intended to contribute to a muchneeded paradigm shift towards geographically stratified and evidence-based planning forP. vivaxcontrol and elimination</p></pwe>…”

Spatial distribution of G6PD deficiency variants across malaria-endemic regions. by Howes, R, Dewi, M, Piel, F, Monteiro, WM, Battle, K, Messina, J, Sakuntabhai, A, Satyagraha, A, Williams, T, Baird, J, Hay, S

The community as the patient in malaria-endemic areas: Preempting drug resistance with multiple first-line therapies. by Boni, M, White, N, Baird, J

Age-specific prevalence of Plasmodium falciparum among six populations with limited histories of exposure to endemic malaria. by Baird, J, Purnomo, Basri, H, Bangs, M, Andersen, E, Jones, T, Masbar, S, Harjosuwarno, S, Subianto, B, Arbani, P

G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. by Howes, R, Piel, F, Patil, A, Nyangiri, O, Gething, P, Dewi, M, Hogg, M, Battle, K, Padilla, C, Baird, J, Hay, S

“…These surveys formed the evidence-base for a Bayesian geostatistical model adapted to the gene's X-linked inheritance, which predicted a G6PDd allele frequency map across malaria endemic countries (MECs) and generated population-weighted estimates of affected populations. …”

Challenges in the Control and Elimination of Plasmodium vivax Malaria by Asih, P, Syafruddin, D, Baird, J

“…This chapter explores many of these challenges and possible approaches in controlling and eliminating endemic vivax malaria.…”

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis. by Price, R, von Seidlein, L, Valecha, N, Nosten, F, Baird, J, White, N

“…BACKGROUND: Chloroquine is the first-line treatment for Plasmodium vivax malaria in most endemic countries, but resistance is increasing. Monitoring of antimalarial efficacy is essential, but in P. vivax infections the assessment of treatment efficacy is confounded by relapse from the dormant liver stages. …”

The global public health significance of Plasmodium vivax. by Battle, K, Gething, P, Elyazar, I, Moyes, C, Sinka, M, Howes, R, Guerra, C, Price, R, Baird, J, Hay, S

“…Here, we review the evidence of the biological limits of its contemporary distribution and the global population at risk (PAR) of the disease within endemic countries. We also review the most recent evidence for the endemic level of transmission within its range and discuss the implications for burden of disease assessments. …”

Evidence and implications of mortality associated with acute Plasmodium vivax malaria. by Baird, J

“…The extraordinary burden of malaria is not heavily weighted upon any single continent by a single species of parasite-it is a complex problem for the entire endemic world, and both species are of fundamental importance. …”