Multi-cellular Rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells by Trichas, G, Smith, A, White, N, Wilkins, V, Watanabe, T, Moore, A, Joyce, B, Sugnaseelan, J, Rodriguez, T, Kay, D, Baker, R, Maini, P, Srinivas, S

“…Our simulations are similar to results from transgenic embryos in which Planar Cell Polarity (PCP) signalling is disrupted. Such embryos have significantly reduced rosette numbers, altered epithelial packing, and show abnormalities in AVE migration. …”

Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells by Trichas, G, Smith, A, White, N, Wilkins, V, Watanabe, T, Moore, A, Joyce, B, Sugnaseelan, J, Rodriguez, T, Kay, D, Baker, R, Maini, P, Srinivas, S

“…Our simulations are similar to results from transgenic embryos in which Planar Cell Polarity (PCP) signalling is disrupted. Such embryos have significantly reduced rosette numbers, altered epithelial packing, and show abnormalities in AVE migration. …”

Testing models of mRNA localization reveals robustness regulated by reducing transport between cells by Harrison, J, Parton, R, Davis, I, Baker, R

“…For example, messenger RNA (mRNA) localization by molecular motor-driven transport is crucial for cell polarization in numerous contexts, but the regulatory mechanisms that enable this process to take place in the face of noise or significant perturbations are not fully understood. …”