Are all antidepressants really the same? The case of fluoxetine: a systematic review. by Cipriani, A, Barbui, C, Brambilla, P, Furukawa, T, Hotopf, M, Geddes, J

“…In terms of tolerability, patients allocated to fluoxetine were less likely to leave the study early only in comparison with those allocated to amitriptyline and pramipexole. CONCLUSIONS: This systematic review highlighted that there are differences between fluoxetine and specific comparator antidepressants. …”

Fluoxetine versus other types of pharmacotherapy for depression by Cipriani, A, Brambilla, P, Furukawa, T, Geddes, J, Gregis, M, Hotopf, M, Malvini, L, Barbui, C

“…Fluoxetine was better tolerated than TCAs considered as a group (Peto OR: 0.78, 95% CI 0.68 to 0.89), and was better tolerated in comparison with individual ADs, in particular than amitriptyline (Peto OR: 0.64, 95% CI 0.47 to 0.85) and imipramine (Peto OR: 0.79, 95% CI 0.63 to 0.99), and among newer ADs than ABT-200 (Peto OR: 0.21, 95% CI 0.10 to 0.41), pramipexole (Peto OR: 0.20, 95% CI 0.08 to 0.47) and reboxetine (Peto OR: 0.61, 95% CI 0.40 to 0.94). …”

Fluoxetine versus other types of pharmacotherapy for depression. by Cipriani, A, Brambilla, P, Furukawa, T, Geddes, J, Gregis, M, Hotopf, M, Malvini, L, Barbui, C

“…Fluoxetine was better tolerated than TCAs considered as a group (PetoOR: 0.78, 95% CI 0.68 to 0.89), and was better tolerated in comparison with individual ADs, in particular than amitriptyline (PetoOR: 0.64, 95% CI 0.47 to 0.85) and imipramine (PetoOR: 0.79, 95% CI 0.63 to 0.99), and among newer ADs than ABT-200 (PetoOR: 0.21, 95% CI 0.10 to 0.41), pramipexole (PetoOR: 0.20, 95% CI 0.08 to 0.47) and reboxetine (PetoOR: 0.61, 95% CI 0.40 to 0.94). …”