Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols by Beattie, K, Bardenet, R, Louttit, J, Vandenberg, J, Hill, A, Gavaghan, D, De Boer, T, Mirams, G

“…Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. …”

Mathematical modelling of drug-ion channel interactions for cardiac safety assessment by Beattie, K

“…</p> <p>We demonstrate how existing mathematical models of hERG channel kinetics can behave very differently when used to simulate the same voltage protocol. …”

Reproducible model development in the cardiac electrophysiology Web Lab by Daly, A, Clerx, M, Beattie, K, Cooper, J, Gavaghan, D, Mirams, G

“…We outline the necessary work to develop a machine-readable language to describe the process of inferring parameters from wet lab datasets, and illustrate our approach through a detailed example of fitting a model of the hERG channel using experimental data. We conclude by discussing the future challenges in making further progress in this domain towards our goal of facilitating a fully reproducible approach to the development of cardiac cell models.…”

Four ways to fit an ion channel model by Clerx, M, Beattie, K, Gavaghan, D, Mirams, G

“…We compare these methods using a set of experiments in which hERG1a current was measured in nine Chinese Hamster Ovary (CHO) cells. …”

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge by Beattie, K, Luscombe, C, Williams, G, Munoz-Muriedas, J, Gavaghan, D, Cui, Y, Mirams, G

“…Methods: Concentration-effect data were acquired from either: the high-throughput IonWorks/FLIPR; the medium-throughput PatchXpress ion channel assays; or QSAR, a statistical IC50 value prediction model, for hERG, fast sodium, L-type calcium and KCNQ1/minK channels. …”

Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge by Beattie, K, Luscombe, C, Williams, G, Munoz−Muriedas, J, Gavaghan, D, Cui, Y, Mirams, G

“…<h3>Methods</h3> Concentration-effect data were acquired from either: the high-throughput IonWorks/FLIPR; the medium-throughput PatchXpress ion channel assays; or QSAR, a statistical IC50 value prediction model, for hERG, fast sodium, L-type calcium and KCNQ1/minK channels. …”