Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations. by Dupuis, C, Storr, H, Perry, L, Ho, J, Ahmed, L, Ong, K, Dunger, D, Monson, J, Grossman, AB, Besser, G, Savage, M

“…A4, DHEAS, T, SHBG, LH and FSH did not correlate with midnight cortisol, but A4 and T SDS correlated with ACTH at 09.00 h (both r = 0.51). …”

Continuous administration of human corticotropin-releasing hormone in the absence of glucocorticoid feedback in man. by Ur, E, Capstick, C, McLoughlin, L, Checkley, S, Besser, G, Grossman, A

“…Circadian rhythm of ACTH was maintained, with a fall in the evening to 14.5 +/- 4 pg/ml (mean +/- SE) at midnight and an exaggerated rise overnight, reaching a peak level of 90 +/- 33 pg/ml at 07:00 h. …”

Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy. by Chan, L, Storr, H, Plowman, P, Perry, L, Besser, G, Grossman, AB, Savage, M

“…Out of 12, 11 patients were cured by RT (cure interval 0.13-2.86 years) defined by mean serum cortisol of <150 nmol/l on 5-point day curve and midnight sleeping cortisol of <50 nmol/l. Long-term data are available for six male patients, who received RT at the age of 7.0-17.6 years. …”

How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome? by Kaltsas, G, Korbonits, M, Isidori, A, Webb, J, Trainer, P, Monson, J, Besser, G, Grossman, AB

“…The diagnosis of CS was based on the presence of appropriate clinical features and an elevated serum midnight cortisol with failure to suppress 0900 hours serum cortisol to less than 50 nmol/l following a formal low-dose dexamethasone suppression test (LDDST). …”

Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome. by Savage, M, Lienhardt, A, Lebrethon, M, Johnston, L, Huebner, A, Grossman, AB, Afshar, F, Plowman, P, Besser, G

“…Cushing's disease was confirmed by detectable serum ACTH, median 28 ng/l (range 12-99, NR <10-50) (n = 15); loss of cortisol circadian rhythm values at midnight ranging from 216 to 1,080 nmol/l (NR <50) (n = 15); lack of cortisol suppression (NV < 50 nmol/l) during low-dose dexamethasone suppression test (LDDST) (0.5 mg 6-hourly x 8) (n = 14); and >50% suppression of cortisol compared with the basal value during high-dose dexamethasone suppression test (HDDST) (2 mg 6-hourly x 8) (n = 14). …”