ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. by Qingyu Li, Zhengyu Zhang, Zengmin Li, Mei Zhou, Bin Liu, Le Pan, Zhixing Ma, Yufang Zheng

“…Our results showed that the radial migration of ADAM17-knocked down cells were normal till E16.5 and reached the intermediate zone (IZ). …”
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Transcription factor Foxp1 stimulates angiogenesis in adult rats after myocardial infarction by Dinghui Wang, Bin Liu, Tianhua Xiong, Wenlong Yu, Huiping Yang, Jing Wang, Xiaodong Jing, Qiang She

“…Adult male rats were subjected to MI, and Foxp1 was knocked down with lentivirus FoxP1 siRNA. Endothelial cell proliferation, angiogenesis, and cardiac function were also assessed. …”
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OsDA1 positively regulates grain width in rice by Cong Li, Jun Liu, Liya Zhang, Tao Li, Hongyu Li, Bin Liu, Tao Zhao

“…Its overexpression led to enlarged seeds with increased width and decreased length/width ratio (LWR) and knocking out OsDA1 reduced grain width and increased grain length and LWR. …”
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Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle Dendroctonus armandi by Bin Liu, Danyang Fu, Hang Ning, Ming Tang, Ming Tang, Hui Chen, Hui Chen

“…Additionally, RNA-interference (RNAi) using double-stranded RNA to knock down SK and SKR reduced the transcription levels of the target genes and increased their body weight. …”
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Klebsiella pneumoniae activates the TGF-β signaling pathway to adhere to and invade intestinal epithelial cells via enhancing TLL1 expression by Jun Liu, Shiliang Zhang, Hao Pei, Fan Tu, Bin Liu, Jie Yan, Xuai Lin

“…Additionally, tolloid-like protein 1 (TLL1) was significantly upregulated. Knocking down TLL1 with shRNA significantly reduced KP1821's ability to invade and adhere to intestinal epithelial cells. …”
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Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer by Hai Yang, Bin Liu, Dongxue Liu, Zhirong Yang, Shuman Zhang, Pengyan Xu, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Grützmann, Christian Pilarsky

“…We performed genome-wide CRISPR/Cas9 knockout screening in the mouse pancreatic cancer cell line TB32047 with gemcitabine treatment and identified deoxycytidine kinase (DCK) and cyclin L1 (CCNL1) as the top hits. We knocked out DCK and CCNL1 in the TB32047 and PANC1 cell lines and confirmed that the loss of DCK or CCNL1 enhanced gemcitabine resistance in pancreatic cells. …”
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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells by Clara Andersson-Rusch, Bin Liu, Ingrid Quist-Løkken, Paul D. Upton, Oddrun Elise Olsen, Hanne Hella, Xudong Yang, Zhen Tong, Nicholas W. Morrell, Toril Holien, Wei Li

“…We have shown that while loss of cell surface ENG decreases BMP9 signaling in endothelial cells, knocking down ENG in blood cancer cells enhances BMP9 signaling. …”
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Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias by Bin Liu, Qing Lou, Heather Smith, Florencia Velez-Cortes, Wolfgang H. Dillmann, Björn C. Knollmann, Antonis A. Armoundas, Sándor Györke

“…In this study, we examined the effect of acute upregulation of SERCA2a on arrhythmogenesis by conditionally overexpressing SERCA2a in a mouse model featuring hyperactive RyR2s due to ablation of calsequestrin 2 (CASQ2). CASQ2 knock-out (KO) mice were crossbred with doxycycline (DOX)-inducible SERCA2a transgenic mice to generate KO-TG mice. …”
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FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression by Jing Ji, Aixin Jing, Yuanyuan Ding, Xinhui Ma, Qilan Qian, Ting Geng, Wenhao Cheng, Meiqi Zhang, Qian Sun, Shaojie Ma, Xiujun Wang, Qing Yuan, Menghan Xu, Jingting Qin, Lin Ma, Jiayan Yang, Jingliang He, Qianming Du, Mengbei Xia, Yuting Xu, Ziyun Chen, Lan Zhu, Wei Liu, Shunfang Liu, Bin Liu

“…Reversal of the apoptosis defects caused by FBXO5 deficiency in colorectal cancer cells can be achieved by knocking down RNF183 in FBXO5-deficient cells. Functionally, we observed significant upregulation of FBXO5 in colon cancer tissues, and its silencing suppresses tumor occurrence in vivo. …”
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ATF3-Induced Mammary Tumors Exhibit Molecular Features of Human Basal-Like Breast Cancer by Leqin Yan, Sally Gaddis, Luis Della Coletta, John Repass, Katherine Leslie Powell, Melissa S. Simper, Yueping Chen, Michelle Byrom, Yi Zhong, Kevin Lin, Bin Liu, Yue Lu, Jianjun Shen, Michael C. MacLeod

“…Finally, we show through knock-down experiments that <i>ATF3</i> may directly modulate <i>MIR145/143</i> expression. …”
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