Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition. by Tsilidis, K, Allen, N, Key, T, Dossus, L, Kaaks, R, Bakken, K, Lund, E, Fournier, A, Dahm, C, Overvad, K, Hansen, L, Tjønneland, A, Rinaldi, S, Romieu, I, Boutron-Ruault, M, Clavel-Chapelon, F, Lukanova, A, Boeing, H, Schütze, M, Benetou, V, Palli, D, Berrino, F, Galasso, R, Tumino, R, Sacerdote, C

“…The association between menopausal hormone therapy (HT) and risk of ovarian cancer was assessed among 126,920 post-menopausal women recruited into the European Prospective Investigation into Cancer and Nutrition. …”

Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. by Tsilidis, K, Allen, N, Key, T, Sanjoaquin, M, Bakken, K, Berrino, F, Fournier, A, Lund, E, Overvad, K, Olsen, A, Tjønneland, A, Byrnes, G, Chajes, V, Rinaldi, S, Boutron-Ruault, M, Clavel-Chapelon, F, Chang-Claude, J, Kaaks, R, Bergmann, M, Boeing, H, Koumantaki, Y, Palli, D, Pala, V, Panico, S, Tumino, R

“…Menopausal hormone therapy (HT) may influence colorectal cancer risk. …”

Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition by Tsilidis, K, Allen, N, Key, T, Dossus, L, Kaaks, R, Bakken, K, Lund, E, Fournier, A, Dahm, C, Overvad, K, Hansen, L, Tjønneland, A, Rinaldi, S, Romieu, I, Boutron-Ruault, M, Clavel-Chapelon, F, Lukanova, A, Boeing, H, Schütze, M, Benetou, V, Palli, D, Berrino, F, Galasso, R, Tumino, R, Sacerdote, C

“…The association between menopausal hormone therapy (HT) and risk of ovarian cancer was assessed among 126,920 post-menopausal women recruited into the European Prospective Investigation into Cancer and Nutrition. …”

Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. by Tsilidis, K, Allen, N, Key, T, Bakken, K, Lund, E, Berrino, F, Fournier, A, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Byrnes, G, Chajes, V, Rinaldi, S, Chang-Claude, J, Kaaks, R, Bergmann, M, Boeing, H, Koumantaki, Y, Stasinopoulou, G, Trichopoulou, A, Palli, D, Tagliabue, G, Panico, S

“…RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. …”

Active and passive cigarette smoking and breast cancer risk: results from the EPIC cohort. by Dossus, L, Boutron-Ruault, M, Kaaks, R, Gram, I, Vilier, A, Fervers, B, Manjer, J, Tjonneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Boeing, H, Steffen, A, Trichopoulou, A, Lagiou, P, Sarantopoulou, M, Palli, D, Berrino, F, Tumino, R, Vineis, P, Mattiello, A, Bueno-de-Mesquita, H, van Duijnhoven, F, Bakker, M, Peeters, P

“…Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). …”

Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. by Schmidt, J, Allen, N, Almquist, M, Franceschi, S, Rinaldi, S, Tipper, S, Tsilidis, K, Weiderpass, E, Overvad, K, Tjønneland, A, Boutron-Ruault, M, Dossus, L, Mesrine, S, Kaaks, R, Lukanova, A, Boeing, H, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Palli, D, Krogh, V, Panico, S, Tumino, R, Zanetti, R, Bueno-de-Mesquita, H

“…The 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study center, sex and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at blood collection. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrit... by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. by Sieri, S, Krogh, V, Ferrari, P, Berrino, F, Pala, V, Thiébaut, A, Tjønneland, A, Olsen, A, Overvad, K, Jakobsen, M, Clavel-Chapelon, F, Chajes, V, Boutron-Ruault, M, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Naska, A, Lagiou, P, Panico, S, Palli, D, Vineis, P, Tumino, R, Lund, E

“…No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. …”

Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition by Sieri, S, Krogh, V, Ferrari, P, Berrino, F, Pala, V, Thiébaut, A, Tjønneland, A, Olsen, A, Overvad, K, Jakobsen, M, Clavel-Chapelon, F, Chajes, V, Boutron-Ruault, M, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Naska, A, Lagiou, P, Panico, S, Palli, D, Vineis, P, Tumino, R, Lund, E

“…No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. …”

Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). by Nagel, G, Linseisen, J, Gils, v, Peeters, P, Boutron-Ruault, M, Clavel-Chapelon, F, Romieu, I, Tjønneland, A, Olsen, A, Roswall, N, Witt, P, Overvad, K, Rohrmann, S, Kaaks, R, Drogan, D, Boeing, H, Trichopoulou, A, Stratigakou, V, Zylis, D, Engeset, D, Lund, E, Skeie, G, Berrino, F, Grioni, S, Mattiello, A

“…All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. …”

Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. by Chuang, S, Norat, T, Murphy, N, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, M, Perquier, F, Dartois, L, Kaaks, R, Teucher, B, Bergmann, M, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Grioni, S, Sacerdote, C, Panico, S, Palli, D, Tumino, R, Peeters, P, Bueno-de-Mesquita, B, Ros, M, Brustad, M

“…DESIGN: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. RESULTS: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. …”

Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). by Murphy, N, Norat, T, Ferrari, P, Jenab, M, Bueno-de-Mesquita, B, Skeie, G, Dahm, C, Overvad, K, Olsen, A, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, M, Racine, A, Kaaks, R, Teucher, B, Boeing, H, Bergmann, M, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Palli, D, Pala, V, Panico, S, Tumino, R, Vineis, P, Siersema, P, van Duijnhoven, F, Peeters, P, Hjartaker, A, Engeset, D, González, C, Sánchez, M, Dorronsoro, M, Navarro, C, Ardanaz, E, Quirós, JR, Sonestedt, E, Ericson, U, Nilsson, L, Palmqvist, R, Khaw, K, Wareham, N, Key, T, Crowe, F, Fedirko, V, Wark, P, Chuang, S, Riboli, E

“…Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. …”

Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study by Buckland, G, Travier, N, Cottet, V, González, C, Luján-Barroso, L, Agudo, A, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Peeters, P, May, A, Bueno-De-Mesquita, H, Bvan Duijnhoven, F, Key, T, Allen, N, Khaw, K, Wareham, N, Romieu, I, McCormack, V, Boutron-Ruault, M, Clavel-Chapelon, F, Panico, S, Agnoli, C, Palli, D, Tumino, R

“…Many factors can affect susceptibility to breast cancer, including menopausal status and diet. This study investigated the association between breast cancer and an adapted version of the "Mediterranean diet," excluding alcohol. …”

Biomarkers of folate and vitamin B12, alcohol intake and breast cancer risk: report from the EPIC cohort by Matejcic, M, Ricci, C, Perrier, F, Huybrechts, I, Buckland, G, Amiano, P, Zeleniuch-Jacquotte, A, Gylling, B, Sieri, S, Key, T, van Gils, C, Peeters, P, Trichopoulou, A, Lagiou, P, Benetou, V, Sánchez, M, His, M, Barricarte, A, Skeie, G, Weiderpass, E, Kaaks, R, Fortner, R, Chirlaque, M, Cox, D, Palli, D, Boutron-Ruault, M, Cadeau, C, Bueno-de-Mesquita, H, Ricceri, F, Quirós, J, Tumino, R, Riboli, E, Romieu, I, Chajès, V

“…Subgroup analyses by menopausal status, hormone receptor status of breast tumors (ER, PR, and HER2), levels of alcohol intake, and MTHFR polymorphisms (677C>T and 1298A>C) were also performed.…”

Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European prospective investigation into cancer and nutrition. by Cust, A, Allen, N, Rinaldi, S, Dossus, L, Friedenreich, C, Olsen, A, Tjønneland, A, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Linseisen, J, Chang-Claude, J, Boeing, H, Schulz, M, Benetou, V, Trichopoulou, A, Trichopoulos, D, Palli, D, Berrino, F, Tumino, R, Mattiello, A, Vineis, P, Quirós, JR, Agudo, A, Sánchez, M

“…Among pre- and post-menopausal women, who were not currently using exogenous hormones, 286 women developed incident endometrial cancer during an average 5.1 years follow-up. …”