Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study by Fedirko, V, Tran, H, Gewirtz, A, Stepien, M, Trichopoulou, A, Aleksandrova, K, Olsen, A, Tjønneland, A, Overvad, K, Carbonnel, F, Boutron-Ruault, M, Severi, G, Kühn, T, Kaaks, R, Boeing, H, Bamia, C, Lagiou, P, Grioni, S, Panico, S, Palli, D, Tumino, R, Naccarati, A, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Castaño, J, Barricarte, A, Sánchez, M, Dorronsoro, M, Quirós, J, Agudo, A, Sjöberg, K, Ohlsson, B, Hemmingsson, O, Werner, M, Bradbury, K, Khaw, K, Wareham, N, Tsilidis, K, Aune, D, Scalbert, A, Romieu, I, Riboli, E, Jenab, M

“…</p><p>METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. …”

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. by Grote, V, Kaaks, R, Nieters, A, Tjønneland, A, Halkjær, J, Overvad, K, Skjelbo Nielsen, MR, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodríguez, L, Duell, E, Sánchez, M

“…METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. …”

Exposure to ambient air pollution and the risk of inflammatory bowel disease: a European nested case-control study by Opstelten, J, Beelen, R, Leenders, M, Hoek, G, Brunekreef, B, van Schaik, F, Siersema, P, Eriksen, K, Raaschou-Nielsen, O, Tjønneland, A, Overvad, K, Boutron-Ruault, M, Carbonnel, F, de Hoogh, K, Key, T, Luben, R, Chan, S, Hart, A, Bueno-de-Mesquita, H, Oldenburg, B

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. by Fedirko, V, Duarte-Salles, T, Bamia, C, Trichopoulou, A, Aleksandrova, K, Trichopoulos, D, Trepo, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Kvaskoff, M, Kühn, T, Lukanova, A, Boeing, H, Buijsse, B, Klinaki, E, Tsimakidi, C, Naccarati, A, Tagliabue, G, Panico, S, Tumino, R, Palli, D, Bueno-de-Mesquita, H

“…Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Prediagnostic serum vitamin D levels and the risk of Crohn’s disease and ulcerative colitis in European populations: a nested case-control study by Opstelten, J, Chan, S, Hart, A, Van Schaik, F, Siersema, P, Lentjes, E, Khaw, K, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Peeters, P, Verschuren, W, Witteman, B, Oldenburg, B

Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. by Leufkens, A, van Duijnhoven, F, Woudt, S, Siersema, P, Jenab, M, Jansen, E, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V

“…This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Dossus, L, McKay, J, Canzian, F, Wilkening, S, Rinaldi, S, Biessy, C, Olsen, A, Tjønneland, A, Jakobsen, M, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fournier, A, Linseisen, J, Lukanova, A, Boeing, H, Fisher, E, Trichopoulou, A, Georgila, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Quirós, JR

“…We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. …”

Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. by Duarte-Salles, T, Fedirko, V, Stepien, M, Trichopoulou, A, Bamia, C, Lagiou, P, Lukanova, A, Trepo, E, Overvad, K, Tjønneland, A, Halkjaer, J, Boutron-Ruault, M, Racine, A, Cadeau, C, Kühn, T, Aleksandrova, K, Trichopoulos, D, Tsiotas, K, Boffetta, P, Palli, D, Pala, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-de-Mesquita, H

“…For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. …”

Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition by Duarte-Salles, T, Fedirko, V, Stepien, M, Trichopoulou, A, Bamia, C, Lagiou, P, Lukanova, A, Trepo, E, Overvad, K, Tjønneland, A, Halkjær, J, Boutron-Ruault, M, Racine, A, Cadeau, C, Kühn, T, Aleksandrova, K, Trichopoulos, D, Tsiotas, K, Boffetta, P, Palli, D, Pala, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-De-Mesquita, H

“…For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. …”

Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). by Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, V, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, H, Peeters, P

“…Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. …”

Smoking as a major risk factor for cervical cancer and pre-cancer: results from the EPIC cohort. by Roura, E, Castellsagué, X, Pawlita, M, Travier, N, Waterboer, T, Margall, N, Bosch, F, de Sanjosé, S, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11, 16, 18, 31, 33, 35, 45, 52, 58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). …”

Smoking as a major risk factor for cervical cancer and pre-cancer: Results from the EPIC cohort by Roura, E, Castellsagué, X, Pawlita, M, Travier, N, Waterboer, T, Margall, N, Bosch, F, De Sanjosé, S, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11, 16, 18, 31, 33, 35, 45, 52, 58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). …”

Prospective seroepidemiologic study on the role of Human Papillomavirus and other infections in cervical carcinogenesis: Evidence from the EPIC cohort by Castellsagué, X, Pawlita, M, Roura, E, Margall, N, Waterboer, T, Bosch, F, De Sanjosé, S, Gonzalez, C, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…To evaluate prospectively the association between serological markers of selected infections, including HPV, and risk of developing cervical cancer (CC) and precancer, we performed a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study that included 184 cases of invasive CC (ICC), 425 cases of cervical intraepithelial neoplasia (CIN) grade 3 or carcinoma in situ (CIS), and 1,218 matched control women. …”

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) coh... by Duell, E, Travier, N, Lujan-Barroso, L, Dossus, L, Boutron-Ruault, M, Clavel-Chapelon, F, Tumino, R, Masala, G, Krogh, V, Panico, S, Ricceri, F, Redondo, M, Dorronsoro, M, Molina-Montes, E, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Allen, N, Travis, R, Siersema, P, Peeters, P, Trichopoulou, A, Fragogeorgi, E, Oikonomou, E

“…Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). …”

Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. by Elena, J, Steplowski, E, Yu, K, Hartge, P, Tobias, G, Brotzman, M, Chanock, S, Stolzenberg-Solomon, R, Arslan, A, Bueno-de-Mesquita, H, Helzlsouer, K, Jacobs, E, LaCroix, A, Petersen, G, Zheng, W, Albanes, D, Allen, N, Amundadottir, L, Bao, Y, Boeing, H, Boutron-Ruault, M, Buring, J, Gaziano, J, Giovannucci, E, Duell, E

“…METHODS: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (&lt;2 years) of pancreatic cancer diagnosis were excluded from all analyses. …”

Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition by Perez-Cornago, A, Appleby, P, Tipper, S, Key, T, Allen, N, Nieters, A, Vermeulen, R, Roulland, S, Casabonne, D, Kaaks, R, Fortner, R, Boeing, H, Trichopoulou, A, La Vecchia, C, Klinaki, E, Hansen, L, Tjønneland, A, Bonnet, F, Fagherazzi, G, Boutron-Ruault, M, Pala, V, Masala, G, Sacerdote, C, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Dorronsoro, M, Quirós, J, Barricarte, A, Gavrila, D, Agudo, A, Borgquist, S, Rosendahl, A, Melin, B, Wareham, N, Khaw, K, Gunter, M, Riboli, E, Vineis, P, Travis, R

“…IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1072 cases of lymphoid malignancies and 1072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. …”

Plasma cotinine levels and pancreatic cancer in the EPIC cohort study. by Leenders, M, Chuang, S, Dahm, C, Overvad, K, Ueland, P, Midttun, O, Vollset, SE, Tjønneland, A, Halkjaer, J, Jenab, M, Clavel-Chapelon, F, Boutron-Ruault, M, Kaaks, R, Canzian, F, Boeing, H, Weikert, C, Trichopoulou, A, Bamia, C, Naska, A, Palli, D, Pala, V, Mattiello, A, Tumino, R, Sacerdote, C, van Duijnhoven, F

“…This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. …”