The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment by Richard E. Frye, Alison Lane, Ashley Worner, Brianna A. Werner, Patrick J. McCarty, Adrienne C. Scheck, Heidi L. Collins, Steven J. Adelman, Edward V. Quadros, Daniel A. Rossignol

“…This is the first report of the sFBPs in ASD. This study complements ongoing controlled clinical trials and suggests that leucovorin may be effective for children with ASD who are positive for sFBPs. …”
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Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder by Richard E. Frye, Patrick J. McCarty, Brianna A. Werner, Adrienne C. Scheck, Heidi L. Collins, Steven J. Adelman, Daniel A. Rossignol, Edward V. Quadros

“…These patients all underwent testing for folate receptor alpha autoantibodies (FRAAs) and soluble folate binding proteins (sFBPs) biomarkers and were treated with leucovorin, if appropriate. …”
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