Characteristics of children with cerebral palsy in the ORACLE children study by Marlow, N, Pike, K, Bower, E, Brocklehurst, P, Jones, D, Kenyon, S, Kurinczuk, J, Taylor, D, Salt, A

“…Aims We have identified an excess of children with cerebral palsy (CP) born to women who received antibiotic treatment for spontaneous preterm labour (SPL). …”

Characteristics of children with cerebral palsy in the ORACLE children study. by Marlow, N, Pike, K, Bower, E, Brocklehurst, P, Jones, D, Kenyon, S, Kurinczuk, J, Taylor, D, Salt, A

“…AIMS: We have identified an excess of children with cerebral palsy (CP) born to women who received antibiotic treatment for spontaneous preterm labour (SPL). …”

Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK--analysis of national data. by Azzopardi, D, Strohm, B, Linsell, L, Hobson, A, Juszczak, E, Kurinczuk, J, Brocklehurst, P, Edwards, A

“…The rates of death fell slightly over the period of the Register and, at two years of age cerebral palsy was diagnosed in 22% of infants; half of these were spastic bilateral. …”

Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid... by Crowther, C, Aghajafari, F, Askie, L, Asztalos, E, Brocklehurst, P, Bubner, T, Doyle, L, Dutta, S, Garite, T, Guinn, D, Hallman, M, Hannah, M, Hardy, P, Maurel, K, Mazumder, P, McEvoy, C, Middleton, P, Murphy, K, Peltoniemi, O, Peters, D, Sullivan, L, Thom, E, Voysey, M, Wapner, R, Yelland, L

“…For the children, the primary study outcomes will be death or any neurological disability (however defined by trialists at childhood follow up and may include developmental delay or intellectual impairment (developmental quotient or intelligence quotient more than one standard deviation below the mean), cerebral palsy (abnormality of tone with motor dysfunction), blindness (for example, corrected visual acuity worse than 6/60 in the better eye) or deafness (for example, hearing loss requiring amplification or worse)). …”

Effects of hypothermia for perinatal asphyxia on childhood outcomes. by Azzopardi, D, Strohm, B, Marlow, N, Brocklehurst, P, Deierl, A, Eddama, O, Goodwin, J, Halliday, H, Juszczak, E, Kapellou, O, Levene, M, Linsell, L, Omar, O, Thoresen, M, Tusor, N, Whitelaw, A, Edwards, A

“…Among survivors, children in the hypothermia group, as compared with those in the control group, had significant reductions in the risk of cerebral palsy (21% vs. 36%, P = 0.03) and the risk of moderate or severe disability (22% vs. 37%, P = 0.03); they also had significantly better motor-function scores. …”

Moderate hypothermia to treat perinatal asphyxial encephalopathy. by Azzopardi, D, Strohm, B, Edwards, A, Dyet, L, Halliday, H, Juszczak, E, Kapellou, O, Levene, M, Marlow, N, Porter, E, Thoresen, M, Whitelaw, A, Brocklehurst, P

“…Among survivors, cooling resulted in reduced risks of cerebral palsy (relative risk, 0.67; 95% CI, 0.47 to 0.96; P=0.03) and improved scores on the Mental Developmental Index and Psychomotor Developmental Index of the Bayley Scales of Infant Development II (P=0.03 for each) and the Gross Motor Function Classification System (P=0.01). …”

Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data by Edwards, A, Brocklehurst, P, Gunn, A, Halliday, H, Juszczak, E, Levene, M, Strohm, B, Thoresen, M, Whitelaw, A, Azzopardi, D

“…Hypothermia increased survival with normal neurological function (risk ratio 1.53, 95% CI 1.22 to 1.93, P<0.001; risk difference 0.12, 95% CI 0.06 to 0.18), with a number needed to treat of eight (95% CI 5 to 17), and in survivors reduced the rates of severe disability (P=0.006), cerebral palsy (P=0.004), and mental and the psychomotor developmental index of less than 70 (P=0.01 and P=0.02, respectively). …”

Association between oxygen saturation targeting and death or disability in extremely preterm infants in the neonatal oxygenation prospective meta-analysis collaboration by Askie, LM, Darlow, BA, Finer, N, Schmidt, B, Stenson, B, Tarnow-Mordi, W, Davis, PG, Carlo, WA, Brocklehurst, P, Davies, LC, Das, A, Rich, W, Gantz, MG, Roberts, RS, Whyte, RK, Costantini, L, Poets, C, Asztalos, E, Battin, M, Halliday, HL, Marlow, N, Tin, W, King, A, Juszczak, E, Morley, CJ, Doyle, LW, Gebski, V, Hunter, KE, Simes, RJ, Neonatal Oxygenation Prospective Meta-Analysis (Neoprom) Collaboration

“…<strong>Main Outcomes and Measures</strong> The primary outcome was a composite of death or major disability (bilateral blindness, deafness, cerebral palsy diagnosed as ≥2 level on the Gross Motor Function Classification System, or Bayley-III cognitive or language score &lt;85) at a corrected age of 18 to 24 months. …”