Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study by Fedirko, V, Tran, H, Gewirtz, A, Stepien, M, Trichopoulou, A, Aleksandrova, K, Olsen, A, Tjønneland, A, Overvad, K, Carbonnel, F, Boutron-Ruault, M, Severi, G, Kühn, T, Kaaks, R, Boeing, H, Bamia, C, Lagiou, P, Grioni, S, Panico, S, Palli, D, Tumino, R, Naccarati, A, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Castaño, J, Barricarte, A, Sánchez, M, Dorronsoro, M, Quirós, J, Agudo, A, Sjöberg, K, Ohlsson, B, Hemmingsson, O, Werner, M, Bradbury, K, Khaw, K, Wareham, N, Tsilidis, K, Aune, D, Scalbert, A, Romieu, I, Riboli, E, Jenab, M

“…</p><p>METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. …”

Exposure to ambient air pollution and the risk of inflammatory bowel disease: a European nested case-control study by Opstelten, J, Beelen, R, Leenders, M, Hoek, G, Brunekreef, B, van Schaik, F, Siersema, P, Eriksen, K, Raaschou-Nielsen, O, Tjønneland, A, Overvad, K, Boutron-Ruault, M, Carbonnel, F, de Hoogh, K, Key, T, Luben, R, Chan, S, Hart, A, Bueno-de-Mesquita, H, Oldenburg, B

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. by Fedirko, V, Duarte-Salles, T, Bamia, C, Trichopoulou, A, Aleksandrova, K, Trichopoulos, D, Trepo, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Kvaskoff, M, Kühn, T, Lukanova, A, Boeing, H, Buijsse, B, Klinaki, E, Tsimakidi, C, Naccarati, A, Tagliabue, G, Panico, S, Tumino, R, Palli, D, Bueno-de-Mesquita, H

“…Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. by Dahm, C, Gorst-Rasmussen, A, Crowe, F, Roswall, N, Tjønneland, A, Drogan, D, Boeing, H, Teucher, B, Kaaks, R, Adarakis, G, Zylis, D, Trichopoulou, A, Fedirko, V, Chajes, V, Jenab, M, Palli, D, Pala, V, Tumino, R, Ricceri, F, van Kranen, H, Bueno-de-Mesquita, H, Quirós, JR, Sánchez, M, Luján-Barroso, L, Larrañaga, N

“…DESIGN: We reanalyzed previously published data from a case-control study of prostate cancer nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Travis, R, Crowe, F, Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Olsen, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Dilis, V, Trichopoulos, D, Vineis, P, Palli, D, Tumino, R, Sieri, S, Bueno-de-Mesquita, H, van Duijnhoven, F, Chirlaque, MD, Barricarte, A, Larrañaga, N, González, C, Argüelles, M, Sánchez, M, Stattin, P, Hallmans, G, Khaw, K, Bingham, S, Rinaldi, S, Slimani, N, Jenab, M, Riboli, E, Key, T

“…The authors examined whether vitamin D concentrations were associated with prostate cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (1994-2000). …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, M, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…Objective: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. Design: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, MD, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…OBJECTIVE: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. DESIGN: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. by Duarte-Salles, T, Fedirko, V, Stepien, M, Trichopoulou, A, Bamia, C, Lagiou, P, Lukanova, A, Trepo, E, Overvad, K, Tjønneland, A, Halkjaer, J, Boutron-Ruault, M, Racine, A, Cadeau, C, Kühn, T, Aleksandrova, K, Trichopoulos, D, Tsiotas, K, Boffetta, P, Palli, D, Pala, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-de-Mesquita, H

“…For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. …”

Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). by Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, V, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, H, Peeters, P

“…Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. …”

Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Key, T, Allen, N, Appleby, P, Roddam, A, Rinaldi, S, Egevad, L, Gann, P, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Sieri, S, Vineis, P, Palli, D, Quirós, JR, Ardanaz, E

“…We examined the hypothesis that serum concentrations of circulating androgens and sex hormone binding globulin (SHBG) are associated with risk for prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: Results from the European prospective investigation into cancer and nutr... by Allen, N, Key, T, Appleby, P, Travis, R, Roddam, A, Rinaldi, S, Egevad, L, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjonneland, A, Gronbaek, H, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Berrino, F, Mattiello, A, Sacerdote, C, Palli, D, Quiros, JR

“…Methods: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). by Nagel, G, Linseisen, J, Boshuizen, H, Pera, G, Del Giudice, G, Westert, G, Bueno-de-Mesquita, H, Allen, N, Key, T, Numans, M, Peeters, P, Sieri, S, Siman, H, Berglund, G, Hallmans, G, Stenling, R, Martinez, C, Arriola, L, Barricarte, A, Chirlaque, MD, Quiros, JR, Vineis, P, Masala, G, Palli, D, Panico, S

“…We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. …”

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutr... by Allen, N, Key, T, Appleby, P, Travis, R, Roddam, A, Rinaldi, S, Egevad, L, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Grønbaek, H, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Berrino, F, Mattiello, A, Sacerdote, C, Palli, D, Quirós, JR

“…METHODS: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. by Ose, J, Fortner, RT, Schock, H, Peeters, P, Onland-Moret, N, Bueno-de-Mesquita, H, Weiderpass, E, Gram, I, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E

“…METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). …”

Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). by Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Johnsen, N, Overvad, K, Boeing, H, Weikert, S, Kaaks, R, Linseisen, J, Trichopoulou, A, Misirli, G, Trichopoulos, D, Sacerdote, C, Grioni, S, Palli, D, Tumino, R, Bueno-de-Mesquita, H, Kiemeney, L, Barricarte, A, Larrañaga, N, Sánchez, M, Agudo, A, Tormo, M, Rodriguez, L

“…OBJECTIVE: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. DESIGN: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Spencer, E, Allen, N, Appleby, P, Roddam, A, Overvad, K, Johnsen, N, Olsen, A, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Bueno-de-Mesquita, H, Ros, M, Sacerdote, C, Palli, D, Tumino, R, Berrino, F, Trichopoulou, A, Dilis, V, Trichopoulos, D, Chirlaque, MD, Ardanaz, E, Larranaga, N, Gonzalez, C

“…We examined plasma concentrations of phyto-oestrogens in relation to risk for subsequent prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. by Elena, J, Steplowski, E, Yu, K, Hartge, P, Tobias, G, Brotzman, M, Chanock, S, Stolzenberg-Solomon, R, Arslan, A, Bueno-de-Mesquita, H, Helzlsouer, K, Jacobs, E, LaCroix, A, Petersen, G, Zheng, W, Albanes, D, Allen, N, Amundadottir, L, Bao, Y, Boeing, H, Boutron-Ruault, M, Buring, J, Gaziano, J, Giovannucci, E, Duell, E

“…METHODS: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (&lt;2 years) of pancreatic cancer diagnosis were excluded from all analyses. …”