Gene expression and hypoxia in breast cancer. by Favaro, E, Lord, S, Harris, A, Buffa, F

“…Hypoxia is a feature of most solid tumors and is associated with poor prognosis in several cancer types, including breast cancer. The master regulator of the hypoxic response is the Hypoxia-inducible factor 1α (HIF-1α). …”

METFORMIN'S EFFECTS ON BREAST CANCER LIPID METABOLISM by Lord, SR, Collins, J, Fielding, B, Buffa, F, Karpe, F, Harris, A

METFORMIN'S EFFECTS ON BREAST CANCER LIPID METABOLISM by Lord, SR, Collins, J, Fielding, B, Buffa, F, Karpe, F, Harris, A

Adaptation to chronic hypoxia in triple-negative breast cancer by Hartley, F

“…Triple-negative breast cancer has the worst prognosis of all breast cancer subtypes with a 5 year survival rate of only 76.7%, and only 10.8% if the cancer has already metastasised. …”

MicroRNA-10b and breast cancer metastasis. by Gee, H, Camps, C, Buffa, F, Colella, S, Sheldon, H, Gleadle, J, Ragoussis, J, Harris, A

Gene expression analysis in human breast cancer associated blood vessels by Jones, D, Lechertier, T, Mitter, R, Herbert, J, Bicknell, R, Jones, J, Li, J, Buffa, F, Harris, A, Hodivala-Dilke, K

“…Overall, our results provide proof-of-principle that our approach can identify a cohort of potentially novel anti-angiogenic targets that are likley to be, but not exclusivley, relevant to breast cancer.…”

In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer by Abu-Jamous, B, Buffa, F, Harris, A, Nandi, A

“…RESULTS: We analyse sixteen heterogeneous breast cancer cell-line transcriptomic datasets in hypoxia-related conditions collectively by employing the unique capabilities of the method, UNCLES, which integrates clustering results from multiple datasets and can address questions that cannot be answered by existing methods. …”

DYNAMIC CONTRAST-ENHANCED MRI REVEALS CORE SIGNALLING PATHWAYS IN BREAST CANCER by Mehta, S, Hughes, N, Buffa, F, Adams, R, Gambhir, S, Harris, A

Overexpression of POLQ confers a poor prognosis in early breast cancer patients. by Higgins, G, Harris, A, Prevo, R, Helleday, T, Mckenna, W, Buffa, F

“…We therefore correlated the clinical outcomes of two retrospective series of patients with early breast cancer with the expression levels of POLQ, as determined by microarray gene expression analysis. …”

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. by Camps, C, Buffa, F, Colella, S, Moore, J, Sotiriou, C, Sheldon, H, Harris, A, Gleadle, J, Ragoussis, J

“…We examined hypoxia-induced miRNA expression changes to identify markers of survival in breast cancer. EXPERIMENTAL DESIGN: We used microarrays to analyze miRNA expression changes induced by hypoxia in MCF7 breast cancer cell lines and validated results by quantitative-PCR (Q-PCR). …”

Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer by Lord, S, Cheng, WC, Liu, D, Gaude, E, Haider, S, Patel, N, Teoh, E, Gleeson, F, Mcgowan, D, Thompson, A, Ah-See, ML, Snell, C, Ayers, L, Karpe, F, Pollak, M, Frezza, C, Fenwick, J, Buffa, F, Harris, A

Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer by Lord, S, Cheng, W, Liu, D, Gaude, E, Haider, S, Metcalf, T, Patel, N, Teoh, E, Gleeson, F, Bradley, K, Wigfield, S, Zois, C, McGowan, D, Ah-See, M, Thompson, A, Sharma, A, Bidaut, L, Pollak, M, Roy, P, Karpe, F, James, T, English, R, Adams, R, Campo, L, Ayers, L, Snell, C, Roxanis, I, Frezza, C, Fenwick, J, Buffa, F, Harris, A

“…We conclude that mitochondrial response to metformin in primary breast cancer may define anti-tumor effect.…”

A semantic interoperability approach to support integration of gene expression and clinical data in breast cancer by Alonso-Calvo, R, Paraiso-Medina, S, Perez-Rey, D, Alonso-Oset, E, Van Stiphout, R, Yu, S, Taylor, M, Buffa, F, Fernandez-Lozano, C, Pazos, A, Maojo, V

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin by Lord, S, Collins, J, Cheng, W, Haider, S, Wigfield, S, Gaude, E, Fielding, B, Pinnick, K, Harjes, U, Segaran, A, Jha, P, Hoefler, G, Pollak, M, Thompson, A, Roy, P, English, R, Adams, R, Frezza, C, Buffa, F, Karpe, F, Harris, A

“…METHODS:Thirty-six patients with untreated primary breast cancer were recruited to a window study and transcriptomic profiling of tumour samples carried out before and after metformin treatment. …”

NUB1 protein regulates cullins and E3 ligases in estrogen receptor negative breast cancers by Tan, K, Haider, S, Zois, C, Turley, H, Leek, R, Harris, A, Buffa, F, Acuto, O, Pezzella, F

Integrating single-cell and spatial transcriptomics in a computational multiscale model of triple negative breast cancer by Victori, P

“…</p> <p>These tools were used together to model triple-negative breast cancer, a disease with an unmet need, focusing on the context of EGFR-targeted treatment. …”

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer by Walsh, CA, Akrap, N, Garre, E, Magnusson, Y, Harrison, H, Andersson, D, Jonasson, E, Rafnsdottir, S, Choudhry, H, Buffa, F, Ragoussis, J, Ståhlberg, A, Harris, A, Landberg, G

“…The definitive characterization of common cancer stem cell (CSCs) subpopulations in breast cancer subtypes with distinct genotypic and phenotypic features remains an ongoing challenge. …”

Aromatase Inhibitors Reduce the Expression of a Hypoxia Metagene in Oestrogen Receptor Positive Breast Cancer in Postmenopausal Women. by Ghazoui, Z, Buffa, F, Dunbier, A, Anderson, H, Dexter, T, Smith, I, Harris, A, Dowsett, M

Factor analysis of predictive markers of response and resistance to primary chemo-endocrine treatment in elderly breast cancer (BC) patients by Generali, D, Fox, S, Buffa, F, Berruti, A, Brizzi, M, Allevi, G, Bonardi, S, Dogliotti, L, Bottini, A, Harris, A

Factor analysis of predictive markers of response and resistance to primary chemo-endocrine treatment in elderly breast cancer (BC) patients by Generali, D, Fox, S, Buffa, F, Berruti, A, Brizzi, M, Bonardi, S, Dogliotti, L, Harris, A, Bottini, A