Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. by Gromada, J, Høy, M, Olsen, H, Gotfredsen, C, Buschard, K, Rorsman, P, Bokvist, K

“…Channel activation was prevented by pre-treating the cells with pertussis toxin, indicating the involvement of G-proteins. …”

Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. by Gromada, J, Høy, M, Buschard, K, Salehi, A, Rorsman, P

“…The inhibitory action of somatostatin was concentration dependent with an IC(50) of 68 nM and prevented by pretreatment of the cells with pertussis toxin. The latter effect was mimicked by intracellular dialysis with specific antibodies to G(i1/2) and by antisense oligonucleotides against G proteins of the subtype G(i2). 4. …”

GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. by Braun, M, Wendt, A, Buschard, K, Salehi, A, Sewing, S, Gromada, J, Rorsman, P

“…The ability of baclofen to suppress exocytosis was prevented by pre-treatment with pertussis toxin and by inclusion of GDPbetaS in the intracellular medium, and became irreversible in the presence of GTPgammaS as expected for a process involving inhibitory G-proteins (Gi/o-proteins). …”