Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions by Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker

“…Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side effect profile that includes hepato- and haema-toxicity. …”
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Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal by Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker

“…Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS infection. A wet media milling top-down approach was used to develop and produce nano co-crystals of 3TC and AZT. …”
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A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals by Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker

“…Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. …”
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Application of Lipid-Based Nanocarriers for Antitubercular Drug Delivery: A Review by Aristote B. Buya, Bwalya A. Witika, Alain M. Bapolisi, Chiluba Mwila, Grady K. Mukubwa, Patrick B. Memvanga, Pedzisai A. Makoni, Christian I. Nkanga

“…The antimicrobial drugs currently used for the management of tuberculosis (TB) exhibit poor bioavailability that necessitates prolonged treatment regimens and high dosing frequency to achieve optimal therapeutic outcomes. …”
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