First Census of Patients with Hereditary Angioedema in the Canary Islands by Alejandro Mendoza-Alvarez, Itahisa Marcelino-Rodriguez, Lourdes Almeida-Quintana, Elena Martin-Fernandez, Dara Martinez-Beltran, Zulay Almeida-Sanchez, David Cruz-Niesvara, Guacimara Hernández-Santana, Jose C. Garcia-Robaina, Carlos Flores, Ariel Callero

“…Recent studies suggested that the regulation of the inflammatory response and the complement cascade are two of the pathways significantly enriched in the Canary Islands, Spain. Here, we describe the first HAE patient series in this region. …”
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Digging into the admixture strata of current-day Canary Islanders based on mitogenomes by Víctor García-Olivares, Luis A. Rubio-Rodríguez, Adrián Muñoz-Barrera, Ana Díaz-de Usera, David Jáspez, Antonio Iñigo-Campos, María Del Cristo Rodríguez Pérez, Antonio Cabrera de León, José M. Lorenzo-Salazar, Rafaela González-Montelongo, Vicente M. Cabrera, Carlos Flores

“…Summary: The conquest of the Canary Islands by Europeans began at the beginning of the 15th century and culminated in 1496 with the surrender of the aborigines. …”
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Developing CIRdb as a catalog of natural genetic variation in the Canary Islanders by Ana Díaz-de Usera, Luis A. Rubio-Rodríguez, Adrián Muñoz-Barrera, Jose M. Lorenzo-Salazar, Beatriz Guillen-Guio, David Jáspez, Almudena Corrales, Antonio Íñigo-Campos, Víctor García-Olivares, María Del Cristo Rodríguez Pérez, Itahisa Marcelino-Rodríguez, Antonio Cabrera de León, Rafaela González-Montelongo, Carlos Flores

“…Abstract The current inhabitants of the Canary Islands have a unique genetic makeup in the European diversity landscape due to the existence of African footprints from recent admixture events, especially of North African components (> 20%). …”
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Mitogenomes illuminate the origin and migration patterns of the indigenous people of the Canary Islands. by Rosa Fregel, Alejandra C Ordóñez, Jonathan Santana-Cabrera, Vicente M Cabrera, Javier Velasco-Vázquez, Verónica Alberto, Marco A Moreno-Benítez, Teresa Delgado-Darias, Amelia Rodríguez-Rodríguez, Juan C Hernández, Jorge Pais, Rafaela González-Montelongo, José M Lorenzo-Salazar, Carlos Flores, M Carmen Cruz-de-Mercadal, Nuria Álvarez-Rodríguez, Beth Shapiro, Matilde Arnay, Carlos D Bustamante

“…The Canary Islands' indigenous people have been the subject of substantial archaeological, anthropological, linguistic and genetic research pointing to a most probable North African Berber source. …”
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Bioinformatic approaches to draft the viral genome sequence of Canary Islands cases related to the multicountry mpox virus 2022-outbreak by Adrián Muñoz-Barrera, Laura Ciuffreda, Julia Alcoba-Florez, Luis A. Rubio-Rodríguez, Héctor Rodríguez-Pérez, Helena Gil-Campesino, Diego García-Martínez de Artola, Josmar Salas-Hernández, Julia Rodríguez-Núñez, Antonio Íñigo-Campos, Víctor García-Olivares, Oscar Díez-Gil, Rafaela González-Montelongo, Agustín Valenzuela-Fernández, José M. Lorenzo-Salazar, Carlos Flores

“…In Europe, several cases of mpox virus (MPXV) infection related to this outbreak were detected in the Canary Islands (Spain). Here we describe the combination of viral DNA sequencing and bioinformatic approaches, including methods for de novo genome assembly and short- and long-read technologies, used to reconstruct the first MPXV genome isolated in the Canary Islands on the 31st of May 2022 from a male adult patient with mild symptoms. …”
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Tracing the trajectories of SARS-CoV-2 variants of concern between December 2020 and September 2021 in the Canary Islands (Spain) by Laura Ciuffreda, Rafaela González-Montelongo, Julia Alcoba-Florez, Diego García-Martínez de Artola, Helena Gil-Campesino, Héctor Rodríguez-Pérez, Antonio Íñigo-Campos, Isabel De Miguel-Martínez, Tomás Tosco-Nuñez, Oscar Díez-Gil, Agustín Valenzuela-Fernández, José M. Lorenzo-Salazar, Carlos Flores, Carlos Flores, Carlos Flores, Carlos Flores

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Reinfection rate and disease severity of the BA.5 Omicron SARS-CoV-2 lineage compared to previously circulating variants of concern in the Canary Islands (Spain) by Laura Ciuffreda, José M. Lorenzo-Salazar, Diego García-Martínez de Artola, Helena Gil-Campesino, Julia Alcoba-Florez, Héctor Rodríguez-Pérez, Antonio Íñigo-Campos, Josmar Salas-Hernández, Julia Rodríguez-Nuñez, Adrián Muñoz-Barrera, Agustín Valenzuela-Fernández, Oscar Díez-Gil, Rafaela González-Montelongo, Carlos Flores

“…To evaluate the impact of this variant on the Canary Islands (Spain) population, we determined the reinfection rates and disease severity associated with the Omicron sublineages and the previously circulating variants of concern. …”
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