Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters by da Silva Antunes, R, Babor, M, Carpenter, C, Khalil, N, Cortese, M, Mentzer, A, Seumois, G, Petro, C, Purcell, L, Vijayanand, P, Crotty, S, Pulendran, B, Peters, B, Sette, A

“…Remarkably, after a contemporary aP booster, cells from donors originally primed with aP were 1) associated with increased IL-4, IL-5, IL-13, IL-9 and TGF-β and decreased IFNγ and IL-17 production;2) defective in their ex vivo capacity to expand memory cells; and 3) less capable to proliferate in vitro. …”