Cardiac stem cell therapy for heart failure by Hsiao, L

“…Independent of etiopathogenesis, heart failure (HF) is the final common stage of numerous heart diseases. …”

Stem cell-based therapy for ischemic heart disease. by Hsiao, L, Carr, C, Chang, K, Lin, S, Clarke, K

“…Despite great advances in therapy over the past decades, ischemic heart disease (IHD) remains the leading cause of death worldwide because the decrease in mortality after acute myocardial infarction (AMI) leads to a longer life span in patients with chronic postinfarct heart failure (HF). …”

Inflammation and insulin resistance in the acutely infarcted rat heart by Catchpole, A, Carr, C, Schneider, J, Tyler, D, Stuckey, D, Clarke, K

Stem cell therapy for the heart: blind alley or magic bullet? by Bruyneel, A, Sehgal, A, Malandraki-Miller, S, Carr, C

“…When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. …”

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart by Hulikova, A, Park, KC, Loonat, A, Rohling, M, Curtis, K, Chung, Y, Wilson, A, Carr, C, Trafford, A, Fournier, M, Moshnikova, A, Andreev, O, Reshetnyak, Y, Riley, P, Smart, N, Milne, T, Crump, N, Swietach, P

Free fatty acids reduce efficiency in the hypertrophied rat heart by Cole, M, Heather, L, Leoni, R, Carr, C, Stuckey, D, Clarke, K

IMPAIRED METABOLIC AND FUNCTIONAL ADAPTATION TO HYPOXIA IN THE TYPE 2 DIABETIC HEART by Mansor, L, Mehta, K, Page, L, Carr, C, Clarke, K, Heather, L

HYPOXIC PRECONDITIONING OF CARDIOSPHERE-DERIVED CELLS TO INCREASE RETENTION IN THE INFARCTED HEART by Tan, S, Le Page, L, Heather, L, Tan, J, Stuckey, D, Carr, C, Clarke, K

Trilayer scaffold with cardiosphere‐derived cells for heart valve tissue engineering by Chen, Q, Bruyneel, A, Carr, C, Czernuszka, J

“…Natural polymers collagen, glycosaminoglycans, and elastin are promising candidate materials for heart valve tissue engineering scaffolds. This work produced trilayer scaffolds that resembled the layered structures of the extracellular matrices of native heart valves. …”

Mechanism of heart failure resulting from chronic beta-adrenergic stimulation by Carr, C, Catchpole, A, Tyler, D, Cole, M, Murray, A, Heather, L, Watson, G, Clarke-Newman, V, Clarke, K

Structural changes in heart and kidney tissue in response to modification of substrate availability by Brisk, K

“…</p> <p>Methods</p> <p>hiPSC-CM in monolayer and in 3D as engineered heart tissue (EHT) were treated with oleic acid to increase maturity, and with palmitic acid and high insulin to induce insulin resistance. …”

In Vivo MRI Tracking of Cardiosphere-Derived Stem Calls In the Infarcted Rat Heart by Carr, C, Stuckey, D, Tan, J, Sweeney, D, Tyler, D, Tan, S, Carter, E, Martin-Rendon, E, Watt, S, Clarke, K

Mechanical and degradation properties of hybrid scaffolds for tissue engineered heart valve (TEHV) by Nazir, R, Bruyneel, A, Carr, C, Czernuszka, JT

“…In addition to biocompatibility, an ideal scaffold for the regeneration of valvular tissue should also replicate the natural heart valve extracellular matrix (ECM) in terms of biomechanical properties and structural stability. …”

Fatty acid-stimulated maturation of human IPSC-derived cardiomyocytes in engineered heart tissue by Purnama, U, Lopez, C, Carr, C

Erythropoietin treatment normalises fatty acid oxidation, but not function, in the chronically infarcted rat heart by Cole, M, Carr, C, Heather, L, Carter, E, Schoemaker, R, Clarke, K

In vivo tracking of mesenchymal stem cells in the infarcted rat heart by magnetic resonance imaging by Stuckey, D, Carr, C, Wilmot, C, Tyler, D, Cassidy, P, Schneider, J, Rendon, E, Watt, S, Clarke, K

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart. by Ball, DR, Rowlands, B, Dodd, M, Le Page, L, Ball, V, Carr, C, Clarke, K, Tyler, D

“…Metabolism was initially assessed in the isolated perfused rat heart, followed by evaluation in the in vivo rat heart. …”

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart. by Murray, A, Lygate, C, Cole, M, Carr, C, Radda, G, Neubauer, S, Clarke, K

“…OBJECTIVE: Many patients with heart failure have whole-body insulin resistance and reduced cardiac fluorodeoxyglucose uptake, but whether these metabolic changes have detrimental effects on the heart is unknown. …”

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction by Barnette, D, Cahill, T, Gunadasa-Rohling, M, Carr, C, Freeman, M, Riley, P

Collagen type I and hyaluronic acid based hybrid scaffolds for heart valve tissue engineering by Nazir, R, Bruyneel, A, Carr, C, Czernuszka, J

“…Cardio sphere‐derived cells (CDCs) from rat hearts showed that crosslinking density affected the available cell attachment sites on the surface of the scaffold. …”