Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. by McAteer, M, Schneider, J, Ali, Z, Warrick, N, Bursill, C, von zur Muhlen, C, Greaves, D, Neubauer, S, Channon, K, Choudhury, R

“…We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis. METHODS AND RESULTS: MPIO (4.5 microm) were conjugated to monoclonal antibodies against vascular cell adhesion molecule-1 (VCAM-MPIO) or P-selectin (P-selectin-MPIO). …”

In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. by McAteer, M, Sibson, N, von Zur Muhlen, C, Schneider, J, Lowe, A, Warrick, N, Channon, K, Anthony, D, Choudhury, R

“…Endothelial vascular cell adhesion molecule-1 (VCAM-1) and its ligand, alpha4beta1 integrin, are key mediators of leukocyte recruitment, and selective inhibitors that bind to the alpha4 subunit of alpha4beta1 substantially reduce clinical relapse in multiple sclerosis. …”

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice. by Schmidt, T, McNeill, E, Douglas, G, Crabtree, M, Hale, AB, Khoo, J, O'Neill, C, Cheng, A, Channon, K, Alp, N

“…BH4 supplementation significantly reduced VCAM-1 (vascular cell adhesion molecule 1) mRNA levels in aortic endothelial cells, markedly reduced the infiltration of T-cells, macrophages and monocytes into plaques, and reduced T-cell infiltration in the adjacent adventitia, but importantly had no effect on circulating leucocytes. …”

A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content by McAteer, M, Mankia, K, Ruparelia, N, Jefferson, A, Nugent, H, Stork, L, Channon, K, Schneider, J, Choudhury, R

“…We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. …”

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. by Fan, L, Douglas, G, Bendall, J, McNeill, E, Crabtree, M, Hale, AB, Mai, A, Li, J, McAteer, M, Schneider, J, Choudhury, R, Channon, K

“…Nox2 transgenic aortas had increased endothelial ROS production, endothelial vascular cell adhesion molecule-1 expression, matrix metalloproteinase activity, and CD45(+) inflammatory cell infiltration. …”

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection by Fan, L, Douglas, G, Bendall, J, McNeill, E, Crabtree, M, Hale, AB, Li, J, McAteer, M, Schneider, J, Choudhury, R, Channon, K

“…Nox2 transgenic aortas had increased endothelial ROS production, endothelial vascular cell adhesion molecule-1 expression, matrix metalloproteinase activity, and CD45+ inflammatory cell infiltration. …”

A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content. by McAteer, M, Mankia, K, Ruparelia, N, Jefferson, A, Nugent, H, Stork, L, Channon, K, Schneider, J, Choudhury, R

“…We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. …”