PSGL-1 is an evolutionarily conserved antiviral restriction factor by Chao Jiang, Miao Mei, Ying Liu, Min Hou, Jun Jiao, Ya Tan, Xu Tan

“…Here we show in vitro and in a knockout mouse model that PSGL-1’s antiviral function is conserved in mice for combating the murine leukemia virus (MLV). In counter-strike, the glycogag or glycoMA proteins encoded by MLV can interact with mouse PSGL-1, which leads to Cul3-KLHL20 E3 ligase-dependent ubiquitination and degradation of PSGL-1. …”
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