Virus morphogenesis and viral entry as alternative targets for novel hepatitis C antivirals by Chapel, C, Zitzmann, N, Zoulim, F, Durantel, D

“…Inhibitors of morphogenesis have recently been identified and studied in different virus–cell systems. …”

Inhibitors of alpha glucosidases impair HCV pseudoparticles morphogenesis, prevent viral secretion and entry into hepatoma cells by Chapel, C, Vuillermoz, I, Bartosch, B, Cosset, F, Zitzmann, N, Dubuisson, J, Dwek, R, Trepo, C, Zoulim, F, Durantel, D

Inhibitors of alpha glucosidases impair HCV pseudoparticles morphogenesis, prevent viral secretion and entry into hepatoma cells by Chapel, C, Durantel, D, Garcia, C, Bartosch, B, Cosset, F, Zitzmann, N, Dubuisson, J, Dwek, R, Trepo, C, Zoulim, F

Alpha-glucosidases inhibitors impair HCV pseudoparticles morphogenesis, prevent viral secretion and entry into hepatoma cells by Chapel, C, Vuillermoz, I, Bartosch, B, Cosset, F, Zitzmann, N, Dwek, R, Dubuisson, J, Trepo, C, Zoulim, F, Durantel, D

“…The morphogenesis of HCV belongs to steps of the viral cycle that have not yet been targeted by antiviral strategies. …”

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles. by Chapel, C, Garcia, C, Roingeard, P, Zitzmann, N, Dubuisson, J, Dwek, R, Trépo, C, Zoulim, F, Durantel, D

“…The inhibitors of morphogenesis studied here target steps of the HCV viral cycle that may prevent or delay viral resistance. …”

Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity by Chapel, C, Garcia, C, Bartosch, B, Roingeard, P, Zitzmann, N, Cosset, F, Dubuisson, J, Dwek, R, Trepo, C, Zoulim, F, Durantel, D

“…As proof of concept, the inhibition of morphogenesis was demonstrated using the BVDV, a pestivirus related to HCV, as a surrogate model. …”

Rôle de la glycosylation des protéines d'enveloppe dans la morphogenèse des Flaviviridae et son inhibition par des antiviraux de nouvelles générations by Chapel, C, Vuillermoz, I, Zitzmann, N, Trépo, C, Zoulim, F, Durantel, D

“…The viral assembly and morphogenesis belong to these new potential targets yet not exploited. …”

Rôle de la glycosylation des protéines d’enveloppe dans la morphogenèse des Flaviviridae et son inhibition par des antiviraux de nouvelles générations by Chapel, C, Vuillermoz, I, Zitzmann, N, Trépo, C, Zoulim, F, Durantel, D

“…The viral assembly and morphogenesis belong to these new potential targets yet not exploited. …”