Cytotoxicity effect of 6-mercaptopurine and 6-mercaptopurine riboside on RAW 264.7 and HIG-82 cell lines by Che Ku Daud, Che Ku Dahlan, Zailani, Muhamad Zulhilmi, Sukiman, Nor Erma Suryana, Tham, Chau Ling, Ahmad, Zuraini, Yong, Yoke Keong, Mohd Zain, Zetty Nadia, Abdullah, Muhammad Nazrul Hakim

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Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo by Che Ku Daud, Che Ku Dahlan

“…In this study, four thiopurine compounds namely, 6- mercaptopurine (6-MP), 6-MP riboside, 6-thioguanine (6-TG) and 6-thioxanthine (6- TX) with diclofenac (a non-steroidal anti-inflammatory drug; NSAID) as positive control were screened for their cytotoxicity and anti-inflammatory properties by evaluating the cell cytotoxicity and the nitric oxide (NO) inhibitory activities upon activated fibroblast synoviocytes (HIG-82) and macrophage (RAW 264.7) cell lines with phorbol-12- myristate acetate (PMA) and lipopolysaccharide (LPS), respectively. …”
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