Inference in molecular population genetics - Discussion by Wilson, L, Stephens, D, Harding, R, Griffiths, B, Joyce, P, Edwards, A, Fearnhead, P, Ewens, W, Beaumont, M, Kuhner, M, Beerli, P, Brooks, S, Gelman, A, Chen, Y, Liu, J, Emond, M, Raftery, A, Steele, R, Felsenstein, J, Larget, B, Markovtsova, L, Marjoram, P, Tavare, S, Mau, B, Meng, X

Adherence to healthy lifestyle and cardiovascular diseases in the Chinese population by Lv, J, Yu, C, Guo, Y, Bian, Z, Yang, L, Chen, Y, Tang, X, Zhang, W, Qian, Y, Huang, Y, Wang, X, Chen, J, Chen, Z, Qi, L, Li, L, China Kadoorie Biobank Collaborative Group

“…BACKGROUND: Adherence to a combination of healthy lifestyle factors has been related to a considerable reduction of cardiovascular risk in white populations; however, little is known whether such associations persist in nonwhite populations like the Asian population. …”

Tea consumption and bone health in Chinese adults: a population-based study by Li, X, Qiao, Y, Yu, C, Guo, Y, Bian, Z, Yang, L, Chen, Y, Yan, S, Xie, X, Huang, D, Chen, J, Chen, Z, Lv, J, Li, L, China Kadoorie Biobank Collaborative Group

“…The sex-specific associations are unrevealed among general population. This study showed that prolonged moderate tea consumption benefited bone health in women, while no additional benefit with stronger tea. …”

Risk of meningioma in patients with head injury: A nationwide population-based study by Kuan, A, Chen, Y, Teng, C, Wang, S, Chen, M

Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study by Kuan, A, Teng, C, Wu, H, Su, V, Chen, Y, Chien, S, Yeh, C, Hu, L, Chen, T, Tzeng, C, Liu, C

Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study by Sun, Q, Yu, D, Fan, J, Yu, C, Guo, Y, Pei, P, Yang, L, Chen, Y, Du, H, Yang, X, Sansome, S, Wang, Y, Zhao, W, Chen, J, Chen, Z, Zhao, L, Lv, J, Li, L

“…Interpretation Our findings suggest that increasing the adoption of these five healthy lifestyle factors through public health interventions could be associated with substantial gains in life expectancy in the Chinese population.…”

PCSK9 genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations by Holmes, M, Kartsonaki, C, Boxall, R, Lin, K, Reeve, N, Yu, C, Lv, J, Bennett, D, Hill, MR, Yang, L, Chen, Y, Du, H, Turnbull, I, Collins, R, Clarke, RJ, Tobin, MD, Li, L, Millwood, IY, Chen, Z, Walters, RG

Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population by Zhu, Y, Zhuang, Z, Lv, J, Sun, D, Pei, P, Yang, L, Chen, Z, Millwood, IY, Walters, RG, Chen, Y, Du, H, Wu, X, Schmidt, D, Avery, D, Chen, J, Li, L, Yu, C

Season and outdoor temperature in relation to detection and control of hypertension in a large rural Chinese population. by Su, D, Du, H, Zhang, X, Qian, Y, Chen, L, Chen, Y, Guo, Y, Bian, Z, Chen, Z, Li, L, Yu, M

“…BACKGROUND: In many Western populations, blood pressure varies moderately with season and outdoor temperature. …”

The hospitalization burden of all-cause pneumonia in China: a population-based study, 2009–2017 by Hu, Y, Han, Y, Yu, C, Guo, Y, Pei, P, Yang, L, Chen, Y, Du, H, Sun, D, Pang, Y, Niu, W, Burgess, S, Hacker, A, Chen, J, Chen, Z, Lv, J, Li, L

“…Generalized linear models were used to examine the secular trends and regional and population variations in pneumonia hospitalization rate, mean length of hospital stay (LOS), and 30-day case fatality rate (CFR). …”

Genetic and healthy lifestyle factors in relation to the incidence and prognosis of severe liver disease in the Chinese population by Pang, Y, Lv, J, Kartsonaki, C, Yu, C, Guo, Y, Chen, Y, Yang, L, Millwood, IY, Walters, RG, Lv, S, Burgess, S, Sansome, S, Chen, J, Chen, Z, Li, L

“…</p> <p><strong>Methods:</strong> The study population included 504,009 participants from the prospective China Kadoorie Biobank aged 30–79 years. …”

Development and external validation of a breast cancer absolute risk prediction model in Chinese population by Han, Y, Lv, J, Yu, C, Guo, Y, Bian, Z, Hu, Y, Yang, L, Chen, Y, Du, H, Zhao, F, Wen, W, Shu, X-O, Xiang, Y, Gao, Y-T, Zheng, W, Guo, H, Liang, P, Chen, J, Chen, Z, Huo, D, Li, L

Observational and genetic associations of body mass index and hepatobiliary diseases in a relatively lean chinese population by Pang, Y, Kartsonaki, C, Lv, J, Millwood, IY, Yu, C, Guo, Y, Chen, Y, Bian, Z, Yang, L, Chen, J, Clarke, R, Walters, R, Wu, S, Li, H, Holmes, MV, Li, L, Chen, Z

“…<strong>Importance: </strong>There is some support for the existence of genetic associations between adiposity and certain hepatobiliary diseases in Western populations. However, there is little evidence of such genetic associations in China, where the causes of these diseases may differ from those in Western populations and the mean body mass index (BMI) is much lower. …”

Development, validation, and evaluation of a risk assessment tool for personalized screening of gastric cancer in Chinese populations by Zhu, X, Lv, J, Zhu, M, Yan, C, Deng, B, Yu, C, Guo, Y, Ni, J, She, Q, Wang, T, Wang, J, Jiang, Y, Chen, J, Hang, D, Song, C, Gao, X, Wu, J, Dai, J, Ma, H, Yang, L, Chen, Y, Song, M, Wei, Q, Chen, Z, Hu, Z, Shen, H, Ding, Y, Li, L, Jin, G

“…We aimed to develop, validate, and evaluate a questionnaire-based GC risk assessment tool for risk prediction and stratification in the Chinese population. <br><strong> Methods<br></strong> In this three-stage multicenter study, we first selected eligible variables by Cox regression models and constructed a GC risk score (GCRS) based on regression coefficients in 416,343 subjects (aged 40–75 years) from the China Kadoorie Biobank (CKB, development cohort). …”

A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates. by Tachmazidou, I, Dedoussis, G, Southam, L, Farmaki, A, Ritchie, G, Xifara, D, Matchan, A, Hatzikotoulas, K, Rayner, N, Chen, Y, Pollin, T, O'Connell, JR, Yerges-Armstrong, L, Kiagiadaki, C, Panoutsopoulou, K, Schwartzentruber, J, Moutsianas, L, Tsafantakis, E, Tyler-Smith, C, McVean, G, Xue, Y, Zeggini, E

“…Approximately 3.8% of individuals are heterozygous for this cardioprotective variant, which was previously thought to be private to the Amish founder population. R19X is rare (&lt;0.05% frequency) in outbred European populations. …”

Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations by Hu, Y, Tanaka, T, Zhu, J, Guan, W, Wu, J, Psaty, B, McKnight, B, King, I, Sun, Q, Richard, M, Manichaikul, A, Frazier-Wood, A, Kabagambe, E, Hopkins, P, Ordovas, J, Ferrucci, L, Bandinelli, S, Arnett, D, Chen, Y, Liang, S, Siscovick, D, Tsai, M, Rich, S, Fornage, M, Hu, F, Rimm, E, Jensen, M, Lemaitre, R, Mozaffarian, D, Steffen, L, Morris, A, Li, H, Lin, X

“…Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry. …”

Associations of muscle mass, strength, and quality with all-cause mortality in China: a population-based cohort study by Wu, M, Wei, Y, Lv, J, Guo, Y, Pei, P, Li, J, Du, H, Yang, L, Chen, Y, Sun, X, Zhang, H, Chen, J, Chen, Z, Yu, C, Li, L

“…Background It remains unclear about the association of muscle mass, strength, and quality with death in the general Chinese population of diverse economical and geographical backgrounds. …”

Ultrafast optical excitation of a persistent surface-state population in the topological insulator Bi2Se3. by Sobota, J, Yang, S, Analytis, J, Chen, Y, Fisher, I, Kirchmann, P, Shen, Z

“…Optical excitation leads to a metastable population at the bulk conduction band edge, which feeds a nonequilibrium population of the surface state persisting for &gt;10 ps. …”

Genome-wide polygenic risk score, cardiometabolic risk factors, and type 2 diabetes mellitus in the Chinese population by Huang, N, Xiao, W, Lv, J, Yu, C, Guo, Y, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Avery, D, Ou, T, Chen, J, Chen, Z, Huang, T, Li, L

“…However, the magnitude of the genetic predisposition of T2D in the Chinese population remains largely unknown.</p> <p><strong>Methods:</strong>&nbsp;This study included&nbsp;93,488 participants from the China Kadoorie Biobank, and multiple polygenic risk scores (PRS) were calculated. …”

Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes by Yao, P, Iona, A, Pozarickij, A, Said, S, Wright, N, Lin, K, Millwood, I, Fry, H, Kartsonaki, C, Mazidi, M, Chen, Y, Bragg, F, Liu, B, Yang, L, Liu, J, Avery, D, Schmidt, D, Sun, D, Pei, P, Lv, J, Yu, C, Hill, M, Bennett, D, Walters, R, Li, L, Clarke, R, Chen, Z