Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics by Pei-Ling Hsieh, Cheng-Chia Yu

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Inhibitory effects of wogonin on invasion by human oral cancer cells by decreasing the activity of matrix metalloproteinases and urokinase-plasminogen activator by Yung-Chuan Ho, Shiuan-Shinn Lee, Shun-Fa Yang, Cheng-Chia Yu, Yu-Chao Chang

“…However, the effects of wogonin on oral cancer cells still remain speculative. Materials and methods: Cytotoxicity and invasion assays were used to investigate the effects of the human oral cancer cell line OC2 cells exposed to wogonin. …”
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Enhanced cisplatin resistance in oral-cancer stem-like cells is correlated with upregulation of excision-repair cross-complementation group 1 by Lo-Lin Tsai, Cheng-Chia Yu, Jeng-Fan Lo, Wen-Wei Sung, Huei Lee, Shiow-Ling Chen, Ming-Yung Chou

“…However, the role of oral-cancer stem-like cells (OC-SLCs) in the chemoresistance of OSCC has not determined. …”
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E3 ligase STUB1 attenuates stemness and tumorigenicity of oral carcinoma cells via transglutaminase 2 regulation by Chia-Ming Liu, Cheng-Chia Yu, Taichen Lin, Yi-Wen Liao, Pei-Ling Hsieh, Chuan-Hang Yu, Shiuan-Shinn Lee

Subjects: “…Oral cancer…”
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LINC01296 promotes cancer stemness traits in oral carcinomas by sponging miR-143 by Kuang-Yuan Liang, Dennis Chun-Yu Ho, Hsiu-Pin Yang, Pei-Ling Hsieh, Chih-Yuan Fang, Lo-Lin Tsai, Shih-Chi Chao, Chia-Ming Liu, Cheng-Chia Yu

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Emerging Role of MicroRNA-200 Family in Dentistry by Pei-Ling Hsieh, Chun-Chung Huang, Cheng-Chia Yu

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Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas by Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu, Horng-Jyh Harn, Cheng-Chia Yu

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Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death by Ching-Chyuan Su, Cheng-Chia Yu, Yi-Wen Shih, Kai-Li Liu, Haw-Wen Chen, Chih-Chung Wu, Ya-Chen Yang, En-Ling Yeh, Chien-Chun Li

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miR-509 inhibits cancer stemness properties in oral carcinomas via directly targeting PlK1 by Ming-Yi Lu, Chih-Yuan Fang, Pei-Ling Hsieh, Yi-Wen Liao, Lo-Lin Tsai, Cheng-Chia Yu

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MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells by Pei-Ling Hsieh, Yi-Wen Liao, Martin Pichler, Cheng-Chia Yu

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LINC00963 Promotes Cancer Stemness, Metastasis, and Drug Resistance in Head and Neck Carcinomas via ABCB5 Regulation by Shiao-Pieng Lee, Pei-Ling Hsieh, Chih-Yuan Fang, Pei-Ming Chu, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Lo-Lin Tsai

“…Stemness phenotypes and the expression of CSCs markers in oral cancer cells transfected with sh-LINC00963 were examined. …”
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miR-146a participates in the regulation of cancer stemness of oral carcinoma cells by Yen-Tze Liu, Cheng-Chia Yu, Ming-Yi Lu, Shih-Chi Chao, Yi-Wen Liao, Chuan-Hang Yu, Yu-Hsien Lee

“…Although ectopic overexpression of micro-RNAs (miRNAs) can modulate the cancer stemness and tumor development in oral cancer, their molecular mechanism is still unclear. …”
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miR-1246 Targets CCNG2 to Enhance Cancer Stemness and Chemoresistance in Oral Carcinomas by Shih-Shen Lin, Chih-Yu Peng, Yi-Wen Liao, Ming-Yung Chou, Pei-Ling Hsieh, Cheng-Chia Yu

“…In the present work, we employed miRNAs RT-PCR analysis to evaluate the expression of miR-1246 in tumor tissues and oral cancer stem cells (OCSC). Stemness phenotypes, including self-renewal, migration, invasion, colony formation capacities, and in vivo oncogenicity of oral cancer cells following transfected with miR-1246 inhibitors or mimics were examined. …”
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Synergistic Effect of Combination of a Temoporfin-Based Photodynamic Therapy with Potassium Iodide or Antibacterial Agents on Oral Disease Pathogens In Vitro by Yin-Hwa Shih, Cheng-Chia Yu, Kai-Chi Chang, Yu-Hsin Tseng, Po-Jung Li, Shih-Min Hsia, Kuo-Chou Chiu, Tzong-Ming Shieh

“…5, 10, 15, 20-Tetrakis(3-hydroxyphenyl)chlorin (temoporfin) is a photosensitizer used in photodynamic therapy for oral cancer and periodontal disease treatment. This study determined the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of temoporfin. …”
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Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis by Chih-Yuan Fang, Szu-Han Chen, Chun-Chung Huang, Yi-Wen Liao, Shih-Chi Chao, Cheng-Chia Yu

“…Oral submucous fibrosis (OSF) is a chronic fibrotic remodeling disease that can progress to oral cancer. However, efficient clinical diagnosis and treatment methods for OSF are still lacking. …”
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miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4 by Yi-Wen Liao, Lo-Lin Tsai, Yu-Hsien Lee, Pei-Ling Hsieh, Cheng-Chia Yu, Ming-Yi Lu

“…Background/purpose: Oral submucous fibrosis (OSF) has been regarded as a premalignant disorder of oral cancer, and myofibroblasts are the main cells that are responsible for pathological fibrosis. …”
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Down-regulation of miR-29c promotes the progression of oral submucous fibrosis through targeting tropomyosin-1 by Po-Yu Yang, Dennis Chun-Yu Ho, Szu-Han Chen, Pei-Ling Hsieh, Yi-Wen Liao, Lo-Lin Tsai, Cheng-Chia Yu, Chih-Yuan Fang

“…The expression of miR-29c is dysregulated in oral cancer, but its role in OSF has not been investigated. …”
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